Beauty Care Product Developing Team, Research and Development Center, Nagase & Co., Ltd., Hyogo, Japan.
J Neurosci Res. 2010 Mar;88(4):896-904. doi: 10.1002/jnr.22242.
Amyotrophic lateral sclerosis (ALS) is a late-onset progressive neurodegenerative disease affecting motor neurons. About 2% of patients with the disease are associated with mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1). The purpose of this study is to assess the effect of rosemary extract and its major constituents, rosmarinic acid (RA) and carnosic acid (CA), in human SOD1 G93A transgenic mice, which are well-established mouse models for ALS. The present study demonstrates that intraperitoneal administration of rosemary extract or RA from the presymptomatic stage significantly delayed motor dysfunction in paw grip endurance tests, attenuated the degeneration of motor neurons, and extended the life span of ALS model mice. In addition, RA administration significantly improved the clinical score and suppressed body weight loss compared with a vehicle-treated group. In conclusion, this study provides the first report that rosemary extract and, especially, RA have preventive effects in the mouse model of ALS.
肌萎缩侧索硬化症（ALS）是一种影响运动神经元的迟发性进行性神经退行性疾病。大约 2%的患者的疾病与编码铜/锌超氧化物歧化酶（SOD1）的基因突变有关。本研究旨在评估迷迭香提取物及其主要成分迷迭香酸（RA）和鼠尾草酸（CA）对人 SOD1 G93A 转基因小鼠的影响，这些小鼠是 ALS 的成熟小鼠模型。本研究表明，从发病前阶段开始腹腔内给予迷迭香提取物或 RA 可显著延迟握力耐力测试中的运动功能障碍，减轻运动神经元的退化，并延长 ALS 模型小鼠的寿命。此外，与对照组相比，RA 给药可显著改善临床评分并抑制体重减轻。总之，这项研究首次报道了迷迭香提取物，特别是 RA，对 ALS 小鼠模型具有预防作用。
