Unité Mixte de Recherches 1136 INRA Nancy University, Interactions Arbres Microorganismes, IFR 110 EFABA, Faculté des Sciences, Vandoeuvre Cedex, France.
Trends Biochem Sci. 2010 Jan;35(1):43-52. doi: 10.1016/j.tibs.2009.08.005. Epub 2009 Oct 5.
Glutaredoxins, proteins traditionally involved in redox reactions, are also required for iron-sulfur cluster assembly and haem biosynthesis. These new roles are probably related to the ability of some glutaredoxins to bind labile [2Fe-2S] clusters and to transfer them rapidly and efficiently to acceptor proteins. Recent results point to putative roles for glutaredoxins in the sensing of cellular iron and in iron-sulfur cluster biogenesis, either as scaffold proteins for the de novo synthesis of iron-sulfur clusters or as carrier proteins for the transfer of preformed iron-sulfur clusters. Based on prokaryote genome analysis and in vivo studies of iron regulation in yeast, we propose putative new roles and binding partners for glutaredoxins in the assembly of metalloproteins.
谷氧还蛋白是传统上参与氧化还原反应的蛋白质，对于铁硫簇的组装和血红素生物合成也是必需的。这些新的作用可能与某些谷氧还蛋白结合不稳定[2Fe-2S]簇并将其快速有效地转移到受体蛋白的能力有关。最近的结果表明，谷氧还蛋白在细胞铁感应和铁硫簇生物发生中可能具有作用，作为铁硫簇从头合成的支架蛋白，或作为预形成铁硫簇转移的载体蛋白。基于原核生物基因组分析和酵母中铁调节的体内研究，我们提出了谷氧还蛋白在金属蛋白组装中的新的可能作用和结合伴侣。
