Bilateral metachronous ovarian metastases from clear cell renal carcinoma: a case report.

INTRODUCTION

Bilateral ovarian metastases from a clear cell renal carcinoma are uncommon findings and need to be differentiated from primary cancers. Diagnostic imaging and histopathological features are often inconclusive, unless they are combined.

CASE PRESENTATION

A 56-year-old woman with a history of right radical nephrectomy for a renal clear cell carcinoma diagnosed 10 years earlier was referred for abdominal distension and pelvic pain. Color-Doppler US and Computer Tomography scan revealed the presence of bilateral ovarian masses with regular margins, a low resistance index and poor contrast enhancement. Immunohistochemistry showed positive epithelial membrane antigen, cytokeratin, vimentin and CD10, suggesting clear cells from the previously diagnosed kidney cancer.

CONCLUSION

Although bilateral metachronous ovarian metastases from clear cell renal carcinoma are a very uncommon finding, they can be considered in the differential diagnosis and investigated with imaging and immunohistochemistry. The 6 cases reported in the literature indicate a good prognosis for this condition.