AmorePacific Corporation R&D Center, Skin Research Institute, Gyeonggi-do, Korea.
Skin Res Technol. 2009 Nov;15(4):464-9. doi: 10.1111/j.1600-0846.2009.00391.x.
BACKGROUND/AIMS: Sensory skin irritation is regarded as one of the most serious side effects of cosmetic use. Thus, it is desirable to develop good inhibitors of sensory skin irritation. However, it is difficult to quantify the effect of sensory skin irritation inhibitors.
We investigated the possibility of using an electrical current perception threshold (CPT) measurement for the quantitative evaluation of these inhibitors. We divided study populations into stinger and non-stinger groups based on their response to 5% lactic acid and assessed CPT values at 2000, 250, and 5 Hz on the cheek. Stingers showed significantly lower CPT values than non-stingers did at 250 and 5 Hz. We also measured CPT values before and after the application of nine materials with inhibitory effects on sensory skin irritation. To investigate the relationship between the change in CPT values and the effect of each material in the clinical stinging test, we conducted the stinging test with the test materials in a 5% lactic acid solution and with a 5% lactic acid solution (positive control).
There was a positive correlation between the change in CPT values and the inhibitory effect that each material had on the stinging test.
The change in CPT values can be used for the quantitative evaluation of sensory skin irritation inhibitors .
背景/目的：感官皮肤刺激被认为是化妆品使用最严重的副作用之一。因此，开发良好的感官皮肤刺激抑制剂是很有必要的。然而，很难定量评估感官皮肤刺激抑制剂的效果。
我们研究了使用电流感知阈值（CPT）测量来定量评估这些抑制剂的可能性。我们根据 5%乳酸引起的反应将研究人群分为刺痛组和非刺痛组，并在脸颊上评估 2000、250 和 5Hz 时的 CPT 值。刺痛组在 250Hz 和 5Hz 时的 CPT 值明显低于非刺痛组。我们还在应用了九种具有感官皮肤刺激抑制作用的材料前后测量了 CPT 值。为了研究 CPT 值变化与临床刺痛试验中每种材料的效果之间的关系，我们用试验材料在 5%乳酸溶液中和 5%乳酸溶液（阳性对照）中进行了刺痛试验。
CPT 值的变化与每种材料对刺痛试验的抑制作用呈正相关。
CPT 值的变化可用于感官皮肤刺激抑制剂的定量评估。
