Ker Jennifer, Hartert Tina V
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennesse 37232-8300, USA.
Ann Allergy Asthma Immunol. 2009 Oct;103(4):282-9. doi: 10.1016/S1081-1206(10)60526-1.
To review and compile data from published studies that provide support for the existence of the atopic march.
Relevant articles and references found via a PubMed search using the following keywords: atopic march, allergic march, atopic dermatitis, eczema, atopic eczema, atopy, rhinitis, wheeze, bronchiolitis, and asthma.
All articles were reviewed and the most relevant were selected for inclusion in this review and for the compilation and graphical presentation of disease trends.
Data on the prevalence of each phenotype of the atopic march confirm the temporal pattern of progression from eczema to allergic rhinitis and asthma. However, the atopic march as it is currently defined, is lacking precision, which affects its usefulness. Early events in the atopic march, such as eczema, may be more useful with more careful refinement of the phenotype into atopic and nonatopic eczema.
Evidence supports that the atopic march is a useful paradigm to describe the clinically observed progression of atopy in certain children. There may be more precise phenotypes of the early stages of the atopic march that may improve its utility in predicting the development of later atopic, comorbid chronic disease.
回顾并汇总已发表研究中的数据，以支持特应性进程的存在。
通过PubMed检索使用以下关键词找到的相关文章及参考文献：特应性进程、过敏性进程、特应性皮炎、湿疹、特应性湿疹、特应性、鼻炎、喘息、细支气管炎和哮喘。
对所有文章进行了评审，并挑选出最相关的文章纳入本综述，用于疾病趋势的汇总和图表展示。
特应性进程各表型患病率的数据证实了从湿疹到过敏性鼻炎和哮喘的时间进展模式。然而，目前所定义的特应性进程缺乏精确性，这影响了其效用。特应性进程中的早期事件，如湿疹，若能更仔细地将表型细化为特应性和非特应性湿疹，可能会更有用。
有证据支持特应性进程是描述某些儿童临床上观察到的特应性进展的有用范例。特应性进程早期阶段可能存在更精确的表型，这可能会提高其在预测后期特应性合并慢性疾病发展方面的效用。
