Trout D L
Carbohydrate Nutrition Laboratory, US Department of Agriculture, Beltsville, MD 20705.
Am J Clin Nutr. 1991 Jan;53(1 Suppl):322S-325S. doi: 10.1093/ajcn/53.1.322S.
The concept that ascorbic acid (vitamin C) supplementation protects against coronary heart disease developed in the late 1970s when vitamin C intakes in industrialized nations were lower than at present. Supplementation was then shown to lower plasma total cholesterol and, among some elderly men, to raise high-density lipoprotein cholesterol. However, among people in initially good vitamin C nutriture, these effects are usually not seen. In five populations of essentially healthy people, blood pressure has been found to correlate negatively with vitamin C status. Recently, in a placebo-controlled, double-blinded study, extra ascorbic acid for 6 wk was observed to lower systolic and pulse pressure in a small group of borderline hypertensive subjects.
抗坏血酸（维生素C）补充剂可预防冠心病这一概念形成于20世纪70年代末，当时工业化国家的维生素C摄入量低于目前水平。随后研究表明，补充维生素C可降低血浆总胆固醇，在一些老年男性中还可提高高密度脂蛋白胆固醇水平。然而，在初始维生素C营养状况良好的人群中，通常看不到这些效果。在五组基本健康的人群中，发现血压与维生素C状况呈负相关。最近，在一项安慰剂对照、双盲研究中，观察到在一小群临界高血压受试者中，连续6周额外补充抗坏血酸可降低收缩压和脉压。
