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高等真菌中的β-葡聚糖及其对健康的影响。

Beta-glucans in higher fungi and their health effects.

机构信息

Department of Food Engineering, Faculty of Technology, Tomas Bata University in Zlin, 762 72 Zlin, Czech Republic.

出版信息

Nutr Rev. 2009 Nov;67(11):624-31. doi: 10.1111/j.1753-4887.2009.00230.x.

DOI:10.1111/j.1753-4887.2009.00230.x
PMID:19906249
Abstract

Together with chitin, the beta-glucans are components of mycetes' cell walls. A high level of biological efficiency has been found in beta-glucans, especially beta-1,3-D-glucans and beta-1,6-D-glucans isolated from some basidiomycetes. (Biological efficiency refers to the relative ability of beta-glucans to promote a desired response, for example to induce leukocyte activation and to produce inflammatory mediators.) These polysaccharides increase the number of Th1 lymphocytes, which help protect organisms against allergic reactions. A number of beta-glucans, for example pleuran from Oyster (Pleurotus spp.) mushrooms or lentinan from Shiitake (Lentinus edodes) mushrooms, have shown marked anticarcinogenic activity. In addition to having an immunity-stimulating effect, beta-glucans may participate in physiological processes related to the metabolism of fats in the human body. Their application results in a decrease in the total cholesterol content in blood and may also contribute to reductions in body weight.

摘要

β-葡聚糖与几丁质一起构成了真菌细胞壁的组成部分。从某些担子菌中分离出的β-1,3-D-葡聚糖和β-1,6-D-葡聚糖具有很高的生物效率。(生物效率是指β-葡聚糖促进所需反应的相对能力,例如诱导白细胞活化和产生炎症介质。)这些多糖增加了 Th1 淋巴细胞的数量,有助于保护机体免受过敏反应的影响。一些β-葡聚糖,例如来自牡蛎(Pleurotus spp.)蘑菇的聚葡萄糖或来自香菇(Lentinus edodes)蘑菇的香菇多糖,具有显著的抗癌活性。除了具有免疫刺激作用外,β-葡聚糖可能还参与与人体脂肪代谢相关的生理过程。它们的应用可降低血液中的总胆固醇含量,并有助于减轻体重。

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