体外实验中，滑膜液可导致人类软骨降解，而细胞因子则不会。
Degradation of human cartilage by synovial fluid but not cytokines in vitro.
作者信息
Hollander A P, Atkins R M, Eastwood D M, Dieppe P A, Elson C J
机构信息
Department of Pathology, University of Bristol, UK.
出版信息
Ann Rheum Dis. 1991 Jan;50(1):57-8. doi: 10.1136/ard.50.1.57.
Abstract
Synovial fluids from patients with rheumatoid arthritis and from patients with osteoarthritis degraded the matrix of living, but not killed, normal human cartilage as judged by loss of glycosaminoglycans. Normal human serum did not degrade living cartilage and neither, unexpectedly, did recombinant human cytokines.
摘要
根据糖胺聚糖的损失判断，类风湿性关节炎患者和骨关节炎患者的滑液会降解正常人类活软骨的基质，但不会杀死软骨。正常人类血清不会降解活软骨，出人意料的是，重组人细胞因子也不会。
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本文引用的文献
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Stimulation by human interleukin 1 of cartilage breakdown and production of collagenase and proteoglycanase by human chondrocytes but not by human osteoblasts in vitro.在体外，人白细胞介素1刺激人软骨细胞导致软骨分解并产生胶原酶和蛋白聚糖酶，但不刺激人成骨细胞。
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Comparison of the in vivo inflammatory activities after intra-articular injection of natural and recombinant IL-1 alpha and IL-1 beta in the rabbit.兔关节腔内注射天然型和重组型白细胞介素-1α及白细胞介素-1β后体内炎症活性的比较。
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Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue.使用二甲基亚甲基蓝改进硫酸化糖胺聚糖的定量和鉴别
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