正常及骨关节炎股骨头软骨的化学成分与肿胀。II. 肿胀
Chemical composition and swelling of normal and osteoarthrotic femoral head cartilage. II. Swelling.
作者信息
Maroudas A, Venn M
出版信息
Ann Rheum Dis. 1977 Oct;36(5):399-406. doi: 10.1136/ard.36.5.399.
Abstract
Studies of the equilibrium, partition, and diffusion of tritiated water were carried out on normal and osteoarthrotic cartilage as well as on cartilage from which proteoglycans had been extracted chemically. All the water was found to be freely exchangeable in both normal and degenerate specimens. The diffusiviity of the water was equal to about 40% of the value in free solution, with an activation energy equal to that in free solution. It was concluded that the swelling of degenerate tissue is not due to any changes in the state of the water, but to a failure of the damaged collagen network to oppose the swelling pressure of the proteoglycans. Swelling similar to that observed in fibrillated cartilage was also found in initially normal specimens treated with collagenase.
摘要
对正常和骨关节炎软骨以及经化学方法提取蛋白聚糖后的软骨进行了氚标记水的平衡、分配和扩散研究。结果发现，在正常和退变标本中，所有的水都是可自由交换的。水的扩散系数约为自由溶液中扩散系数值的40%，其活化能与自由溶液中的活化能相同。得出的结论是，退变组织的肿胀不是由于水的状态发生任何变化，而是由于受损的胶原网络无法抵抗蛋白聚糖的肿胀压力。在用胶原酶处理的初始正常标本中也发现了类似于在纤维化软骨中观察到的肿胀现象。
相似文献
1
Chemical composition and swelling of normal and osteoarthrotic femoral head cartilage. II. Swelling.
Ann Rheum Dis. 1977 Oct;36(5):399-406. doi: 10.1136/ard.36.5.399.
2
Chemical composition and swelling of normal and osteoarthrotic femoral head cartilage. I. Chemical composition.
Ann Rheum Dis. 1977 Apr;36(2):121-9. doi: 10.1136/ard.36.2.121.
3
Biochemical changes in progressive osteoarthrosis.
Ann Rheum Dis. 1977 Oct;36(5):387-98. doi: 10.1136/ard.36.5.387.
4
Proteoglycan synthesis in chondrocyte cultures from osteoarthrotic and normal human articular cartilage.
Biochim Biophys Acta. 1982 Aug 6;717(2):190-202. doi: 10.1016/0304-4165(82)90169-6.
5
Metabolism of human femoral head cartilage in osteoarthrosis and subcapital fracture.
Ann Rheum Dis. 1981 Feb;40(1):18-26. doi: 10.1136/ard.40.1.18.
6
Correlation of histopathology and sulfated proteoglycans in human osteoarthritic hip cartilage.
J Orthop Res. 1984;1(3):302-12. doi: 10.1002/jor.1100010310.
7
Chemical composition of normal and osteoarthrotic cancellous bone of the femoral head. Studies of EDTA extracts and collagenase digests.
Arch Orthop Trauma Surg (1978). 1984;102(4):267-72. doi: 10.1007/BF00436142.
8
Further studies on the composition of human femoral head cartilage.
Ann Rheum Dis. 1980 Oct;39(5):514-23. doi: 10.1136/ard.39.5.514.
9
Sulphated glycosaminoglycan synthesis in normal and osteoarthrotic hip cartilage.
Ann Rheum Dis. 1977 Aug;36(4):369-73. doi: 10.1136/ard.36.4.369.
10
Cartilage and osteoarthrosis: changes of collagen and proteoglycans.
Czech Med. 1979;2(1-2):64-8.
引用本文的文献
1
Modeling Osmotic Deswelling of Composite Hydrogels with Finite Element Analysis.
Polymer (Guildf). 2025 Aug 13;333. doi: 10.1016/j.polymer.2025.128634. Epub 2025 Jun 1.
2
Metabolic and molecular imaging in inflammatory arthritis.
RMD Open. 2024 Feb 9;10(1):e003880. doi: 10.1136/rmdopen-2023-003880.
3
The Influence of Knee Position on Ultrasound Imaging of Femoral Cartilage in Individuals with Anterior Cruciate Ligament Reconstruction.
Cartilage. 2024 Jun;15(2):84-93. doi: 10.1177/19476035231205682. Epub 2023 Oct 16.
4
T2 mapping magnetic resonance imaging of cartilage in hemophilia.
Res Pract Thromb Haemost. 2023 Aug 23;7(6):102182. doi: 10.1016/j.rpth.2023.102182. eCollection 2023 Aug.
5
T1rho MR properties of human patellar cartilage: correlation with indentation stiffness and biochemical contents.
Skeletal Radiol. 2024 Apr;53(4):649-656. doi: 10.1007/s00256-023-04458-6. Epub 2023 Sep 23.
6
Imaging in inflammatory arthritis: progress towards precision medicine.
Nat Rev Rheumatol. 2023 Oct;19(10):650-665. doi: 10.1038/s41584-023-01016-1. Epub 2023 Sep 8.
7
Modeling Inelastic Responses Using Constrained Reactive Mixtures.
Eur J Mech A Solids. 2023 Jul-Aug;100. doi: 10.1016/j.euromechsol.2023.105009. Epub 2023 May 6.
8
Optics-Free, In Situ Swelling Monitoring of Articular Cartilage with Graphene Strain Sensors.
ACS Biomater Sci Eng. 2023 Feb 13;9(2):1011-1019. doi: 10.1021/acsbiomaterials.2c01456. Epub 2023 Jan 26.
9
Biofabrication of the osteochondral unit and its applications: Current and future directions for 3D bioprinting.
J Tissue Eng. 2022 Nov 6;13:20417314221133480. doi: 10.1177/20417314221133480. eCollection 2022 Jan-Dec.
10
Exploring the role of intratendinous pressure in the pathogenesis of tendon pathology: a narrative review and conceptual framework.
Br J Sports Med. 2023 Aug;57(16):1042-1048. doi: 10.1136/bjsports-2022-106066. Epub 2022 Nov 2.
本文引用的文献
1
Biochemical Findings in Normal and Osteoarthritic Articular Cartilage. II. Chondroitin Sulfate Concentration and Chain Length, Water, and Ash Content.
J Clin Invest. 1966 Jul;45(7):1170-7. doi: 10.1172/JCI105423.
2
[Quantitative colorimetric test for collagenase].
Hoppe Seylers Z Physiol Chem. 1960 Dec 31;322:267-72. doi: 10.1515/bchm2.1960.322.1.267.
3
Physicochemical properties of cartilage in the light of ion exchange theory.
Biophys J. 1968 May;8(5):575-95. doi: 10.1016/S0006-3495(68)86509-9.
4
The properties of molecular fragments obtained on treating calfskin collagen with collagenase from Clostridium histolyticum.
Eur J Biochem. 1968 Dec 5;6(4):534-41. doi: 10.1111/j.1432-1033.1968.tb00477.x.
5
Comparative sequence studies of rat skin and tendon collagen. I. Evidence for incomplete hydroxylation of individual prolyl residues in the normal proteins.
Biochemistry. 1967 Oct;6(10):3082-93. doi: 10.1021/bi00862a015.
6
Preparation of insoluble collagen from human cartilage.
Biochem J. 1973 Sep;135(1):245-7. doi: 10.1042/bj1350245.
7
Cartilage of the hip joint. Topographical variation of glycosaminoglycan content in normal and fibrillated tissue.
Ann Rheum Dis. 1973 Jan;32(1):1-9. doi: 10.1136/ard.32.1.1.
8
Identification and concentration of the glycosaminoglycans of human articular cartilage in relation to age and osteoarthritis.
Calcif Tissue Res. 1972;10(3):223-37. doi: 10.1007/BF02012552.
9
A simple physicochemical micromethod for determining fixed anionic groups in connective tissue.
Biochim Biophys Acta. 1970 Jul 21;215(1):214-6.
10
Distribution and diffusion of solutes in articular cartilage.
Biophys J. 1970 May;10(5):365-79. doi: 10.1016/S0006-3495(70)86307-X.
Zotero 插件