正常及骨关节炎股骨头软骨的化学成分与肿胀。II. 肿胀
Chemical composition and swelling of normal and osteoarthrotic femoral head cartilage. II. Swelling.
作者信息
Maroudas A, Venn M
出版信息
Ann Rheum Dis. 1977 Oct;36(5):399-406. doi: 10.1136/ard.36.5.399.
Abstract
Studies of the equilibrium, partition, and diffusion of tritiated water were carried out on normal and osteoarthrotic cartilage as well as on cartilage from which proteoglycans had been extracted chemically. All the water was found to be freely exchangeable in both normal and degenerate specimens. The diffusiviity of the water was equal to about 40% of the value in free solution, with an activation energy equal to that in free solution. It was concluded that the swelling of degenerate tissue is not due to any changes in the state of the water, but to a failure of the damaged collagen network to oppose the swelling pressure of the proteoglycans. Swelling similar to that observed in fibrillated cartilage was also found in initially normal specimens treated with collagenase.
摘要
对正常和骨关节炎软骨以及经化学方法提取蛋白聚糖后的软骨进行了氚标记水的平衡、分配和扩散研究。结果发现，在正常和退变标本中，所有的水都是可自由交换的。水的扩散系数约为自由溶液中扩散系数值的40%，其活化能与自由溶液中的活化能相同。得出的结论是，退变组织的肿胀不是由于水的状态发生任何变化，而是由于受损的胶原网络无法抵抗蛋白聚糖的肿胀压力。在用胶原酶处理的初始正常标本中也发现了类似于在纤维化软骨中观察到的肿胀现象。
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