Department of Chemistry, Portland State University, Portland, OR 97207, USA.
Food Chem Toxicol. 2010 Feb;48(2):755-63. doi: 10.1016/j.fct.2009.12.015. Epub 2010 Jan 13.
Nicotine and flavorant compound levels were measured in 10 "mint"-related sub-brands and 8 "wintergreen" sub-brands of smokeless tobacco (SLT). Also analyzed were "mint"-related and "wintergreen" confectionery products. Of the "mint" SLT, "Timberwolf Packs Mint Pouches" contained the highest menthol level (5.3 mg/g); the average for the five most-highly mentholated SLT products was 4.3 mg/g. The average for the most five most-highly mentholated confectionery products was 3.5 mg/g. For hard candy, a reported average of maximum use levels is 2.1 mg/g (Burdock, 2009). Of the "wintergreen" SLT, "Hawken Wintergreen" was found to contain the highest methyl salicylate (MS) level (29.7 mg/g). The average of the five highest SLT MS levels was 23.8 mg/g, i.e., 5x higher than the level found in the confectionery product with the highest MS level (LifeSavers Wint O Green Sugar Free, 4.6 mg/g). For hard candy, a reported average of maximum use levels is 2.0 mg/g (Burdock, 2009). Assuming 23.8 mg/g MS in SLT, SLT use at 15 g/day, 100% bodily absorption of the MS, and 60 kg body weight, the average daily intake would be 6.0 mg/kg-day, i.e., 12x the acceptable daily intake (ADI) of 0.5 mg/kg-day established for this compound by a joint FAO/WHO committee.
对 10 种“薄荷”相关的无烟烟草（SLT）子品牌和 8 种“冬绿”子品牌，以及“薄荷”和“冬绿”相关糖果制品中的尼古丁和调味剂含量进行了测量。在“薄荷”SLT 中，“Timberwolf Packs Mint Pouches”中薄荷脑含量最高（5.3mg/g）；5 种含高浓度薄荷脑的 SLT 产品的平均含量为 4.3mg/g。5 种含高浓度薄荷脑的糖果制品的平均含量为 3.5mg/g。对于硬糖，据报道，最高使用水平的平均报告值为 2.1mg/g（Burdock，2009 年）。在“冬绿”SLT 中，“Hawken Wintergreen”被发现含有最高的水杨酸甲酯（MS）含量（29.7mg/g）。5 种 MS 含量最高的 SLT 的平均含量为 23.8mg/g，即比含有最高 MS 水平的糖果制品（LifeSavers Wint O Green Sugar Free，4.6mg/g）高 5 倍。对于硬糖，据报道，最高使用水平的平均报告值为 2.0mg/g（Burdock，2009 年）。假设 SLT 中的 MS 含量为 23.8mg/g，SLT 每天使用 15g，MS 吸收率为 100%，体重为 60kg，则平均每日摄入量为 6.0mg/kg-day，即 0.5mg/kg-day 日允许摄入量（ADI）的 12 倍，该 ADI 是由 FAO/WHO 联合委员会为该化合物确定的。
