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The mysteries of induced pluripotency: where will they lead?

作者信息

Nagy Andras, Nagy Kristina

机构信息

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

出版信息

Nat Methods. 2010 Jan;7(1):22-4. doi: 10.1038/nmeth.f.292.

DOI:10.1038/nmeth.f.292
PMID:20038951
Abstract
摘要

相似文献

1
The mysteries of induced pluripotency: where will they lead?诱导多能性的奥秘：它们将引领我们走向何方？
Nat Methods. 2010 Jan;7(1):22-4. doi: 10.1038/nmeth.f.292.
2
Stem cells: Troublesome memories.干细胞：棘手的记忆。
Nature. 2010 Sep 16;467(7313):280-1. doi: 10.1038/467280a.
3
Induced pluripotent stem cells : it looks simple but can looks deceive?诱导多能干细胞：看似简单，但其表象是否具有欺骗性？
Stem Cells. 2010 May;28(5):845-50. doi: 10.1002/stem.411.
4
Epigenetic memory in induced pluripotent stem cells.诱导多能干细胞中的表观遗传记忆。
Nature. 2010 Sep 16;467(7313):285-90. doi: 10.1038/nature09342.
5
High throughput sequencing identifies an imprinted gene, Grb10, associated with the pluripotency state in nuclear transfer embryonic stem cells.高通量测序鉴定出一个与核移植胚胎干细胞多能性状态相关的印记基因Grb10。
Oncotarget. 2017 Jul 18;8(29):47344-47355. doi: 10.18632/oncotarget.17185.
6
Concise review: Induced pluripotent stem cells versus embryonic stem cells: close enough or yet too far apart?简明综述：诱导多能干细胞与胚胎干细胞：足够接近还是相差甚远？
Stem Cells. 2012 Jan;30(1):33-41. doi: 10.1002/stem.700.
7
iPS cells: potent stuff.诱导多能干细胞：强大的物质。
Nat Methods. 2010 Jan;7(1):17-9. doi: 10.1038/nmeth.f.281.
8
Epigenetics of induced pluripotency, the seven-headed dragon.诱导多能干细胞的表观遗传学：七头龙。
Stem Cell Res Ther. 2010 Mar 15;1(1):3. doi: 10.1186/scrt3.
9
The 3D genome shapes up for pluripotency.三维基因组为多能性提供了形态。
Cell Stem Cell. 2013 Jul 3;13(1):3-4. doi: 10.1016/j.stem.2013.06.013.
10
Toward directed reprogramming through exogenous factors.通过外源因子实现定向重编程。
Curr Opin Genet Dev. 2013 Oct;23(5):519-25. doi: 10.1016/j.gde.2013.06.002. Epub 2013 Aug 8.

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Cells. 2025 May 26;14(11):781. doi: 10.3390/cells14110781.
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Microfluidic chip systems for characterizing glucose-responsive insulin-secreting cells equipped with FailSafe kill-switch.配备故障安全自毁开关的用于表征葡萄糖响应性胰岛素分泌细胞的微流控芯片系统。
Stem Cell Res Ther. 2024 Dec 18;15(1):486. doi: 10.1186/s13287-024-04059-7.
3
Deconstructing age reprogramming.解构年龄重编程。

本文引用的文献

1
Direct cell reprogramming is a stochastic process amenable to acceleration.直接细胞重编程是一个适合加速的随机过程。
Nature. 2009 Dec 3;462(7273):595-601. doi: 10.1038/nature08592. Epub 2009 Nov 8.
2
Elite and stochastic models for induced pluripotent stem cell generation.诱导多能干细胞生成的精英模型和随机模型。
Nature. 2009 Jul 2;460(7251):49-52. doi: 10.1038/nature08180.
3
piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells.piggyBac转座将成纤维细胞重编程为诱导多能干细胞。
J Biosci. 2019 Sep;44(4).
4
Interrupted reprogramming of alveolar type II cells induces progenitor-like cells that ameliorate pulmonary fibrosis.肺泡II型细胞重编程中断诱导祖细胞样细胞，改善肺纤维化。
NPJ Regen Med. 2018 Sep 4;3:14. doi: 10.1038/s41536-018-0052-5. eCollection 2018.
5
Reprogramming, oscillations and transdifferentiation in epigenetic landscapes.重编程、震荡和表观遗传景观中的转分化。
Sci Rep. 2018 May 9;8(1):7358. doi: 10.1038/s41598-018-25556-9.
6
Generation of Induced Progenitor-like Cells from Mature Epithelial Cells Using Interrupted Reprogramming.利用中断重编程技术从成熟上皮细胞生成诱导祖细胞样细胞。
Stem Cell Reports. 2017 Dec 12;9(6):1780-1795. doi: 10.1016/j.stemcr.2017.10.022. Epub 2017 Nov 30.
7
Transcription factor-mediated reprogramming: epigenetics and therapeutic potential.转录因子介导的重编程：表观遗传学与治疗潜力
Immunol Cell Biol. 2015 Mar;93(3):284-9. doi: 10.1038/icb.2015.5. Epub 2015 Feb 3.
8
Delayed self-regulation and time-dependent chemical drive leads to novel states in epigenetic landscapes.延迟的自我调节和时间依赖性化学驱动导致表观遗传景观中的新状态。
J R Soc Interface. 2014 Nov 6;11(100):20140706. doi: 10.1098/rsif.2014.0706.
9
Epigenome rejuvenation: HP1β mobility as a measure of pluripotent and senescent chromatin ground states.表观基因组年轻化：以HP1β的移动性作为多能性和衰老染色质基态的一种衡量指标
Sci Rep. 2014 Apr 25;4:4789. doi: 10.1038/srep04789.
10
The role of single-cell analyses in understanding cell lineage commitment.单细胞分析在理解细胞谱系决定中的作用。
Biotechnol J. 2013 Apr;8(4):397-407. doi: 10.1002/biot.201200201. Epub 2013 Mar 21.
Nature. 2009 Apr 9;458(7239):766-70. doi: 10.1038/nature07863. Epub 2009 Mar 1.
4
Heterokaryon-based reprogramming of human B lymphocytes for pluripotency requires Oct4 but not Sox2.基于异核体的人类B淋巴细胞重编程为多能性需要Oct4，但不需要Sox2。
PLoS Genet. 2008 Sep 5;4(9):e1000170. doi: 10.1371/journal.pgen.1000170.
5
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.通过特定因子从小鼠胚胎和成体成纤维细胞培养物中诱导多能干细胞。
Cell. 2006 Aug 25;126(4):663-76. doi: 10.1016/j.cell.2006.07.024. Epub 2006 Aug 10.
6
Transplantation of Living Nuclei From Blastula Cells into Enucleated Frogs' Eggs.将囊胚细胞的活细胞核移植到去核的蛙卵中。
Proc Natl Acad Sci U S A. 1952 May;38(5):455-63. doi: 10.1073/pnas.38.5.455.
7
Adult frogs derived from the nuclei of single somatic cells.成年青蛙源自单个体细胞的细胞核。
Dev Biol. 1962 Apr;4:256-73. doi: 10.1016/0012-1606(62)90043-x.
8
Viable offspring derived from fetal and adult mammalian cells.源自胎儿和成年哺乳动物细胞的可存活后代。
Nature. 1997 Feb 27;385(6619):810-3. doi: 10.1038/385810a0.
9
Cytoplasmic activation of human nuclear genes in stable heterocaryons.稳定异核体中人类核基因的细胞质激活
Cell. 1983 Apr;32(4):1171-80. doi: 10.1016/0092-8674(83)90300-8.
10
Inability of mouse blastomere nuclei transferred to enucleated zygotes to support development in vitro.转移至去核受精卵中的小鼠卵裂球细胞核无法在体外支持胚胎发育。
Science. 1984 Dec 14;226(4680):1317-9. doi: 10.1126/science.6542249.