采用门控检测技术的全身体实时临床前量子点荧光成像。
Whole-body, real-time preclinical imaging of quantum dot fluorescence with time-gated detection.
出版信息
J Biomed Opt. 2009 Nov-Dec;14(6):060504. doi: 10.1117/1.3269675.
Abstract
We describe a wide-field preclinical imaging system optimized for time-gated detection of quantum dot fluorescence emission. As compared to continuous wave measurements, image contrast was substantially improved by suppression of short-lifetime background autofluorescence. Real-time (8 frames/s) biological imaging of subcutaneous quantum dot injections is demonstrated simultaneously in multiple living mice.
摘要
我们描述了一种优化的宽场临床前成像系统，用于门控检测量子点荧光发射。与连续波测量相比，通过抑制短寿命背景荧光的本底，显著提高了图像对比度。同时对多只活体小鼠进行了实时（8 帧/秒）的皮下量子点注射的生物成像。
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