DuPont Agricultural Biotechnology Group and Pioneer Hi-Bred International, Wilmington, DE, USA.
Curr Opin Plant Biol. 2010 Apr;13(2):174-80. doi: 10.1016/j.pbi.2009.12.004. Epub 2010 Jan 19.
Increased availability of high throughput genotyping technology together with advances in DNA sequencing and in the development of statistical methodology appropriate for genome-wide association scan mapping in presence of considerable population structure contributed to the increased interest association mapping in plants. While most published studies in crop species are candidate gene-based, genome-wide studies are on the increase. New types of populations providing for increased resolution and power of detection of modest-size effects and for the analysis of epistatic interactions have been developed. Classical biparental mapping remains the method of choice for mapping the effects of alleles rare in germplasm collections, such as some disease resistance genes or alleles introgressed from exotic germplasm.
高通量基因分型技术的可用性提高，加上 DNA 测序技术的进步，以及在存在大量群体结构的情况下适用于全基因组关联扫描映射的统计方法学的发展，都促使人们对植物的关联映射产生了浓厚的兴趣。虽然大多数在作物物种中发表的研究都是基于候选基因的，但全基因组研究的数量正在增加。已经开发了新类型的群体，这些群体提供了更高的分辨率和检测适度大小效应的能力，并能够分析上位性相互作用。经典的双亲图谱仍然是选择方法，用于映射稀有遗传资源中等位基因的效应，例如一些抗病基因或从外来遗传资源中导入的等位基因。
