Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N.P. Marg, Matunga (E), Mumbai 400019, Maharashtra, India.
J Pharm Sci. 2010 Jun;99(6):2576-81. doi: 10.1002/jps.22052.
The role of particle size and surface modification on biodistribution of nanocarriers is widely reported. We report for the first time the role of nanoparticle shape on biodistribution. Our study demonstrates that irregular shaped polymer lipid nanoparticles (LIPOMER) evade kupffer cells and localize in the spleen. We also demonstrate the macrophage-evading characteristic of the irregular-shaped LIPOMER. Our results suggest particle shape as an important tool for passive targeting of nanocarriers in splenotropic drug delivery.
粒径和表面修饰对纳米载体的生物分布的作用已被广泛报道。我们首次报道了纳米颗粒形状对生物分布的作用。我们的研究表明，形状不规则的聚合物脂质纳米颗粒（LIPOMER）可以逃避库普弗细胞并定位于脾脏。我们还证明了形状不规则的 LIPOMER 具有逃避巨噬细胞的特性。我们的结果表明，颗粒形状是实现脾靶向药物递送的纳米载体被动靶向的重要工具。
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