Nestlé Research Centre, Switzerland.
Food Chem Toxicol. 2010 Jan;48 Suppl 1:S106-11. doi: 10.1016/j.fct.2009.10.018.
Sudan I is generally considered mutagenic based on various in vitro and in vivo tests and is carcinogenic in the rat. Dose-response modelling of the data for hepatocellular adenomas in male rats gave a BMDL(10) of 7.3mg/kg-bw/day. Sudan I is an unauthorised substance that might be present in food intermittently. The great variability and uncertainties in the human exposure data which are country specific, depending on consumption patterns and methodology used, resulted in a large range of MOE values (from 30 to 2,000,000).
苏丹红 I 一般被认为具有诱变作用，这基于各种体外和体内试验，并且在大鼠中具有致癌性。对雄性大鼠肝细胞腺瘤数据进行剂量反应建模，得出 BMDL(10)为 7.3mg/kg-bw/天。苏丹红 I 是一种未经授权的物质，可能会间歇性地存在于食物中。由于各国的消费模式和所用方法不同，人体暴露数据存在很大的变异性和不确定性，导致 MOE 值范围很广（从 30 到 200 万）。
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