应用暴露边际（MoE）方法评估食品中遗传毒性和致癌物质：示例：苯，CAS 号：71-43-2。
Application of the Margin of Exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: benzene, CAS: 71-43-2.
机构信息
Firmenich S.A., Switzerland.
出版信息
Food Chem Toxicol. 2010 Jan;48 Suppl 1:S49-56. doi: 10.1016/j.fct.2009.10.015.
PMID:20113854
Abstract
The role of genotoxic events in the aetiology of benzene induced tumours cannot be ruled out. Dose response modelling of the data for benzene gave a BMDL10 for female Zymbal gland carcinoma of 17.6 mg/kg-bw/d following adjustment to daily average doses. The MOEs ranged from 2 x 10(6) to 0.4 x 10(6) depending on the assumptions used in the exposure estimation.
摘要
遗传毒性事件在苯诱导肿瘤的发病机制中所起的作用尚不能排除。对苯数据进行的剂量反应建模得出，雌性大鼠的津巴尔氏腺肿瘤的 BMDL10 值为 17.6mg/kg-bw/d，此值在调整为日平均剂量后得出。MOE 值范围在 2 x 10(6) 到 0.4 x 10(6) 之间，具体取决于在暴露估计中使用的假设。
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