应用暴露边际（MoE）方法评估食品中具有遗传毒性和致癌性的物质：示例：（CAS 编号：96-23-1）1,3-二氯-2-丙醇（DCP）。

Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: (CAS No. 96-23-1) 1,3-dichloro-2-propanol (DCP).

机构信息

New York Medical College, USA.

出版信息

Food Chem Toxicol. 2010 Jan;48 Suppl 1:S57-62. doi: 10.1016/j.fct.2009.10.038.

DOI:10.1016/j.fct.2009.10.038

PMID:20113855

Abstract

1,3-Dichloro-2-propanol (DCP) is formed in foods under a variety of conditions. It was positive in a variety of in vitro genotoxicity tests, but was negative in two in vivo studies. DCP produced neoplasms at several sites in rats. Kidney tumours in male rats were selected as the critical tumour type. Dose-response modelling of the data for DCP gave a BMDL(10) for combined kidney carcinomas and adenomas in male rats of 9.62 mg/kg-body weight (bw)/day. The exposure of humans was estimated at an average of 0.00009 mg/kg-bw/day and a high exposure of 0.000136 mg/kg-bw/day. The MOEs for these exposures were 100,000 and 70,000, respectively.

摘要

1,3-二氯-2-丙醇（DCP）在各种条件下都会在食品中形成。它在各种体外遗传毒性试验中呈阳性，但在两项体内研究中呈阴性。DCP 可使大鼠的多个部位产生肿瘤。雄性大鼠的肾脏肿瘤被选为关键肿瘤类型。对 DCP 数据进行剂量反应建模，得出雄性大鼠肾脏癌和腺瘤联合的 BMDL（10）值为 9.62 毫克/公斤体重/天。估计人类的暴露量平均为 0.00009 毫克/公斤体重/天，高暴露量为 0.000136 毫克/公斤体重/天。这些暴露量的 MOE 分别为 100000 和 70000。