Unilever Research, UK.
Food Chem Toxicol. 2010 Jan;48 Suppl 1:S98-105. doi: 10.1016/j.fct.2009.10.035.
PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) is a heterocyclic amine and genotoxic carcinogen contaminant that occurs during the grilling and frying of meat and fish, through an interaction between sugars and creatine via the Maillard reaction. PhIP causes cancers of the prostate, mammary gland and colon in rodents. Dose-response modelling of the data for these three tumour types gives BMDL10 values of 0.48 mg/kg/day for the prostate tumours, 0.74 mg/kg/day for mammary tumours and 2.71 mg/kg/day for colon tumours. The lowest MOEs for prostate, mammary and colon tumours were 20,000, 40,000 and 150,000, respectively.
2-氨基-1-甲基-6-苯基咪唑[4,5-b]吡啶（PhIP）是一种杂环胺和遗传毒性致癌污染物，在烤肉和煎鱼过程中，通过美拉德反应，糖和肌酸之间的相互作用而产生。PhIP 可引起啮齿动物的前列腺癌、乳腺癌和结肠癌。对这三种肿瘤类型的数据进行剂量反应建模，得到前列腺肿瘤的 BMDL10 值为 0.48mg/kg/天，乳腺肿瘤为 0.74mg/kg/天，结肠肿瘤为 2.71mg/kg/天。前列腺、乳腺和结肠肿瘤的最低 MOE 值分别为 20000、40000 和 150000。
