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应用暴露边际（MoE）方法评估食品中遗传毒性和致癌性物质：例如：甲基丁香酚，CASRN：93-15-2。

Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: methyleugenol, CASRN: 93-15-2.

机构信息

Firmenich S.A., Switzerland.

出版信息

Food Chem Toxicol. 2010 Jan;48 Suppl 1:S89-97. doi: 10.1016/j.fct.2009.10.036.

DOI:10.1016/j.fct.2009.10.036
PMID:20113858
Abstract

The weight of evidence points to weak genotoxic activity of methyleugenol, the putative genotoxic carcinogen being 1'-sulphate ester metabolite. Dose response modelling of the data for methyleugenol gave a BMDL10 for male rat liver adenoma or carcinoma (combined) of 7.9 mg/kg-bw/d following adjustment to daily average doses. The MoEs ranged from 100 to 800 depending on the assumptions used in the exposure estimation.

摘要

证据表明，丁香酚的遗传毒性活性较弱，而被认为具有遗传毒性的致癌物质是 1'-硫酸盐酯代谢物。对丁香酚数据进行剂量反应建模后发现，雄性大鼠肝腺瘤或癌（合并）的 BMDL10 值为 7.9mg/kg-bw/d，经调整为每日平均剂量后得出。根据暴露估计中使用的假设，MoE 值范围从 100 到 800 不等。

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