Firmenich S.A., Switzerland.
Food Chem Toxicol. 2010 Jan;48 Suppl 1:S89-97. doi: 10.1016/j.fct.2009.10.036.
The weight of evidence points to weak genotoxic activity of methyleugenol, the putative genotoxic carcinogen being 1'-sulphate ester metabolite. Dose response modelling of the data for methyleugenol gave a BMDL10 for male rat liver adenoma or carcinoma (combined) of 7.9 mg/kg-bw/d following adjustment to daily average doses. The MoEs ranged from 100 to 800 depending on the assumptions used in the exposure estimation.
证据表明，丁香酚的遗传毒性活性较弱，而被认为具有遗传毒性的致癌物质是 1'-硫酸盐酯代谢物。对丁香酚数据进行剂量反应建模后发现，雄性大鼠肝腺瘤或癌（合并）的 BMDL10 值为 7.9mg/kg-bw/d，经调整为每日平均剂量后得出。根据暴露估计中使用的假设，MoE 值范围从 100 到 800 不等。
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