应用暴露边际（MOE）方法评估食品中具有遗传毒性和致癌性的物质。示例：亮绿。

Application of the margin of exposure (MOE) approach to substances in food that are genotoxic and carcinogenic. Example: leucomalachite green.

机构信息

University of Southampton, UK.

出版信息

Food Chem Toxicol. 2010 Jan;48 Suppl 1:S75-80. doi: 10.1016/j.fct.2009.09.025. Epub 2009 Sep 26.

DOI:10.1016/j.fct.2009.09.025

Abstract

Leucomalachite green (LMG) is mutagenic and produces DNA-adducts in vivo, and is carcinogenic in rodent bioassays. Dose-response modelling of the data for hepatocellular adenomas and carcinomas in female mice gave a BMDL10 of 20 mg/kg-bw/day. Limited data are available on the concentrations present in fish for human consumption. Human exposure estimates assumed that all consumed fish is contaminated with LMG. The calculated MoEs were 4,000,000 and 400,000 respectively for average and high exposure estimates.

摘要

白色孔雀石绿（LMG）具有致突变性，并在体内产生 DNA 加合物，在啮齿动物生物测定中具有致癌性。对雌性小鼠肝细胞腺瘤和癌的数据进行剂量反应建模，得出 BMDL10 为 20mg/kg-bw/天。关于供人类食用的鱼类中存在的浓度的可用数据有限。人类接触量的估计假设所有食用的鱼类都受到 LMG 的污染。对于平均和高暴露量估计，计算出的 MOE 分别为 4000000 和 400000。

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