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应用暴露边际（MoE）方法评估食品中具有遗传毒性和致癌性的物质：示例：呋喃（CAS 号 110-00-9）。

Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: furan (CAS No. 110-00-9).

机构信息

Unilever Research, UK.

出版信息

Food Chem Toxicol. 2010 Jan;48 Suppl 1:S69-74. doi: 10.1016/j.fct.2009.10.017.

DOI:10.1016/j.fct.2009.10.017
PMID:20113857
Abstract

Furan is commonly found in foods such as coffee, canned and jarred foods, including baby food containing meat, and various vegetables. It is thought to be formed by the thermal decomposition of carbohydrates. Furan is carcinogenic in rodents, although the detailed mechanism of action has not been completely established, for all the tumour types induced. Dose-response modelling of the data for hepatocellular tumours gives a BMDL10 of 1.23 mg/kg/day, and MOEs of between 750 and 4300 for exposures of infants and adults.

摘要

糠醛普遍存在于咖啡、罐装和瓶装食品中，包括含肉的婴儿食品和各种蔬菜。它被认为是由碳水化合物的热分解形成的。糠醛在啮齿动物中具有致癌性，尽管其所有诱导肿瘤类型的作用机制尚未完全确定。对肝细胞肿瘤数据的剂量反应建模得出 1.23 毫克/公斤/天的 BMDL10，婴儿和成人暴露的 MOE 在 750 到 4300 之间。

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