Federal Office of Public Health, Switzerland.
Food Chem Toxicol. 2010 Jan;48 Suppl 1:S63-8. doi: 10.1016/j.fct.2009.10.032.
Ethyl carbamate is mutagenic and produces DNA-adducts in vivo, and is carcinogenic in rodent bioassays. Dose-response modelling of the data for alveolar and bronchiolar adenoma or carcinoma in male and female mice combined gave a BMDL(10) of 0.25 mg/kg-bw/day. The dietary exposure from consumption of foods and non-alcoholic beverage was estimated to be 1 microg/person/day (15 ng/kg-bw/day), while the exposure of a high-percentile consumer of alcoholic beverages was estimated to be 5 microg/person per day (80 ng/kg-bw/day). The corresponding calculated MOEs were 16600 and 3125, respectively.
氨基甲酸乙酯具有致突变性，并在体内产生 DNA 加合物，在啮齿动物生物测定中具有致癌性。对雄性和雌性小鼠的肺泡和细支气管腺瘤或癌的数据进行剂量反应建模，得出每日每公斤体重 0.25 毫克的 BMDL(10)。通过食用食物和非酒精性饮料摄入的饮食暴露量估计为每人 1 微克/天（15 纳克/公斤体重/天），而高酒精饮料消费者的暴露量估计为每人每天 5 微克（80 纳克/公斤体重/天）。相应的计算 MOE 分别为 16600 和 3125。
