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应用暴露边际（MoE）方法评估食品中具有遗传毒性和致癌性的物质：示例：黄曲霉毒素 B1（AFB1）。

Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: aflatoxin B1 (AFB1).

机构信息

Food Standards Agency, UK.

出版信息

Food Chem Toxicol. 2010 Jan;48 Suppl 1:S34-41. doi: 10.1016/j.fct.2009.10.037.

DOI:10.1016/j.fct.2009.10.037
PMID:20113853
Abstract

Aflatoxin B1 (AFB1) has been consistently shown to be a potent mutagen and is a liver carcinogen in humans and a wide range of animal species. The Fisher rat appears to be the most sensitive animal model. Dose-response modelling results in a BMDL(10) of 250 ng/kg-bw/d. Estimates of mean dietary exposure estimates were 0.4 ng/kg-bw/d and 2.6 ng/kg-bw/d, representing regions with low and high exposure, respectively. The MOEs for mean exposure therefore range from 100 to 600.

摘要

黄曲霉毒素 B1（AFB1）已被证实是一种强效诱变剂，也是人类和多种动物的肝脏致癌物。费舍尔大鼠似乎是最敏感的动物模型。剂量反应模型得出的 BMDL(10)值为 250ng/kg-bw/d。平均膳食暴露估计值分别为 0.4ng/kg-bw/d 和 2.6ng/kg-bw/d，分别代表低暴露和高暴露区域。因此，平均暴露的 MOE 范围从 100 到 600。

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