Lemos M F L, van Gestel C A M, Soares A M V M
CESAM and Department of Biology, University of Aveiro, 3810-193, Aveiro, Portugal.
Arch Environ Contam Toxicol. 2010 Aug;59(2):274-81. doi: 10.1007/s00244-010-9474-9. Epub 2010 Feb 11.
Studies of the effects of endocrine-disrupting compounds (EDCs) on invertebrates are still largely underrepresented. This work aims to fill this gap by assessing the effects of bisphenol A (BPA) and vinclozolin (Vz) on the terrestrial isopod Porcellio scaber (common rough woodlouse). Male adult and sexually undifferentiated juvenile woodlice were exposed to the toxicants. Effects on molting regime and growth were investigated independently for males and female woodlice after sexual differentiation. Both chemicals elicited developmental toxicity to P. scaber by causing overall decreased growth. Nevertheless, BPA induced molting, whereas Vz delayed it. Although the LC50 values for juvenile and adult survival were fairly similar, juvenile woodlice showed an increased chronic sensitivity to both chemicals, and female woodlice were most the sensitive to BPA. We recommend the use of adults, juveniles, female, and male woodlice, as well as a large range of toxicant concentrations, to provide valuable information regarding differential dose responses, effects, and threshold values for EDCs.
关于内分泌干扰化合物（EDCs）对无脊椎动物影响的研究仍然很不充分。这项工作旨在通过评估双酚A（BPA）和乙烯菌核利（Vz）对陆生等足动物普通卷甲虫（Porcellio scaber）的影响来填补这一空白。成年雄性和未分化性别的幼年卷甲虫暴露于这些毒物中。在性别分化后，分别研究了对雄性和雌性卷甲虫蜕皮机制和生长的影响。两种化学物质都通过导致总体生长下降而引发了对普通卷甲虫的发育毒性。然而，双酚A诱导蜕皮，而乙烯菌核利则延迟蜕皮。尽管幼年和成年卷甲虫存活的半数致死浓度（LC50）值相当相似，但幼年卷甲虫对两种化学物质的慢性敏感性增加，并且雌性卷甲虫对双酚A最为敏感。我们建议使用成年、幼年、雌性和雄性卷甲虫，以及大范围的毒物浓度，以提供有关内分泌干扰化合物的不同剂量反应、影响和阈值的有价值信息。
