Umamaheswari M, Chatterjee T K
Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.
Afr J Tradit Complement Altern Med. 2007 Oct 27;5(1):61-73.
The present study was aimed at investigating the antioxidant activities of the various fractions of the hydromethanolic extract of the leaves of Coccinia grandis L. Voigt. (Cucurbitaceae). The antioxidant activities of the fractions have been evaluated by using nine in vitro assays and were compared to standard antioxidants such as ascorbic acid, alpha-tocopherol, curcumin and butylated hydroxyl toluene (BHT). All the fractions showed effective H-donor activity, reducing power, free radical scavenging activity, metal chelating ability and inhibition of beta-carotene bleaching. None of the fractions exerted an obvious pro-oxidant activity. The antioxidant property depends upon concentration and increased with increasing amount of the fractions. The free radical scavenging and antioxidant activities may be attributed to the presence of phenolic and flavonoid compounds present in the fractions. The results obtained in the present study indicate that the leaves of C. grandis are a potential source of natural antioxidant.
本研究旨在调查大籽栝楼（Coccinia grandis L. Voigt.，葫芦科）叶片水甲醇提取物各组分的抗氧化活性。通过九种体外试验评估了各组分的抗氧化活性，并与抗坏血酸、α-生育酚、姜黄素和丁基羟基甲苯（BHT）等标准抗氧化剂进行了比较。所有组分均表现出有效的氢供体活性、还原能力、自由基清除活性、金属螯合能力以及对β-胡萝卜素漂白的抑制作用。没有一个组分表现出明显的促氧化活性。抗氧化性能取决于浓度，并随组分含量的增加而增强。自由基清除和抗氧化活性可能归因于组分中存在的酚类和黄酮类化合物。本研究获得的结果表明，大籽栝楼叶片是天然抗氧化剂的潜在来源。
