Bae Ki Hyun, Kim Young Beom, Lee Yuhan, Hwang Jinyoung, Park Hyunwook, Park Tae Gwan
Department of Biological Sciences and Graduate School of Nanoscience and Technology, and Department of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, South Korea.
Bioconjug Chem. 2010 Mar 17;21(3):505-12. doi: 10.1021/bc900424u. Epub 2010 Feb 18.
Gadolinium-labeled magnetite nanoparticles (GMNPs) were synthesized via a bioinspired manner to use as dual contrast agents for T1- and T2-weighted magnetic resonance imaging. A mussel-derived adhesive moiety, 3,4-dihydroxy-l-phenylalanine (DOPA), was utilized as a robust anchor to form a mixed layer of poly(ethylene glycol) (PEG) chains and dopamine molecules on the surface of iron oxide nanoparticles. Gadolinium ions were subsequently complexed at the distal end of the dopamine molecules that were prefunctionalized with a chelating ligand for gadolinium. The resultant GMNPs exhibited high dispersion stability in aqueous solution. Crystal structure and superparamagnetic properties of magnetite nanocrystals were also maintained after the complexation of gadolinium. The potential of GMNPs as dual contrast agents for T1 and T2-weighted magnetic resonance imaging was demonstrated by conducting in vitro and in vivo imaging and relaxivity measurements.
钆标记的磁铁矿纳米颗粒（GMNPs）通过仿生方式合成，用作T1加权和T2加权磁共振成像的双重造影剂。一种贻贝来源的粘附部分，3,4-二羟基-L-苯丙氨酸（DOPA），被用作强力锚定剂，在氧化铁纳米颗粒表面形成聚乙二醇（PEG）链和多巴胺分子的混合层。随后，钆离子在预先用钆螯合配体功能化的多巴胺分子的远端进行络合。所得的GMNPs在水溶液中表现出高分散稳定性。钆络合后，磁铁矿纳米晶体的晶体结构和超顺磁性也得以保持。通过进行体外和体内成像以及弛豫率测量，证明了GMNPs作为T1和T2加权磁共振成像双重造影剂的潜力。
Mater Sci Eng C Mater Biol Appl. 2014-4-28
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