从微小花棘豆的地上部分中分离得到的两种新的三萜皂苷。

Two new triterpene saponins from the aerial parts of Paraquilegia microphylla.

机构信息

Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.

出版信息

Fitoterapia. 2010 Sep;81(6):581-5. doi: 10.1016/j.fitote.2010.02.004. Epub 2010 Feb 20.

DOI:10.1016/j.fitote.2010.02.004

PMID:20176088

Abstract

Two new triterpene saponins, paraquinosides A (1) and B (2) were isolated from the aerial parts of Paraquilegia microphylla (Royle) Dromm. et Hutch, a Tibetan ethnic medicine distributed in the Qinghai-Tibet Plateau. On the basis of 1D and 2D NMR evidence, their structure was elucidated as 3-O-alpha-L-rhamnopyranosyl (1-->2)-beta-D-glucopyranosyl-15-dehydroxyl-16-O-methyl-24, 25-deoxy-26-hydroxylshengmanol-26-O-beta-D-glucopyranoside (1) and 3-O-alpha-L-Rhamnopyranosyl (1-->2)-[beta-D-glucopyranosyl(1-->3)]-beta-D-glucopyranosyl-15-dehydroxyl-16-O-methyl-24, 25-deoxy-26-hydroxylshengmanol-26-O-beta-D- glucopyranoside (2), respectively.

摘要

从分布于青藏高原的藏药短瓣绿绒蒿（Paraquilegia microphylla （Royle） Dromm. et Hutch）的地上部分分离得到两种新的三萜皂苷，paraquinoside A（1）和 B（2）。根据 1D 和 2D NMR 证据，其结构被阐明为 3-O-α-L-鼠李吡喃糖基（1-->2）-β-D-吡喃葡萄糖基-15-去羟基-16-O-甲基-24,25-去氧-26-羟基生曼醇-26-O-β-D-吡喃葡萄糖苷（1）和 3-O-α-L-鼠李吡喃糖基（1-->2）-[β-D-吡喃葡萄糖基（1-->3）]-β-D-吡喃葡萄糖基-15-去羟基-16-O-甲基-24,25-去氧-26-羟基生曼醇-26-O-β-D-吡喃葡萄糖苷（2）。