Shahid Humma, Salmon John F
Oxford Eye Hospital, West Wing, Oxford Radcliffe Hospitals NHS Trust, Oxford, OX3 9DU, UK.
J Med Case Rep. 2010 Jan 29;4:27. doi: 10.1186/1752-1947-4-27.
The intravenous use of fluorescein 10% during retinal angiography can cause severe systemic reactions including, on rare occasions, anaphylaxis. Fluorescein 2% eye drops are used extensively for clinical examination and diagnosis, but to the best of our knowledge, they have only been reported as being responsible for a systemic anaphylactic response on two previous occasions.
We report the case of a 51-year-old woman who developed an anaphylactic reaction when she was administered fluorescein sodium 2% eye drops after cataract surgery. This was the second time she had been exposed to fluorescein. She had brittle asthma and a history of anaphylaxis following exposure to a variety of drug and food allergens. She was successfully resuscitated and recovered completely over a period of two days.
Fluorescein 2% drops are universally used in general practice, ophthalmology, optometry, and casualty departments. Our case report reveals the potential for this benign eye drop to cause a life-threatening systemic reaction and emphasises the importance of considering this consequence when administering topical fluorescein 2% to a patient with a history of anaphylaxis to other allergens.
视网膜血管造影术中静脉注射10%荧光素可引起严重的全身反应，包括罕见的过敏反应。2%荧光素滴眼液广泛用于临床检查和诊断，但据我们所知，此前仅有两次报告称其导致全身过敏反应。
我们报告一例51岁女性病例，该患者在白内障手术后使用2%荧光素钠滴眼液时发生过敏反应。这是她第二次接触荧光素。她患有脆性哮喘，有接触多种药物和食物过敏原后发生过敏反应的病史。她成功复苏，并在两天内完全康复。
2%荧光素滴眼液在普通科、眼科、验光科和急诊科普遍使用。我们的病例报告揭示了这种良性滴眼液可能导致危及生命的全身反应，并强调了对有其他过敏原过敏史的患者使用局部2%荧光素时考虑这一后果的重要性。
