Department of Anesthesiology and Intensive Care, Medical School, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.
Ren Fail. 2010 Jan;32(3):391-5. doi: 10.3109/08860221003611752.
Ischemia/reperfusion (I/R) occurs in a number of pathological conditions, including myocardial infarction, stroke, aortic surgery, cardiopulmonary bypass surgery, organ transplantation, resuscitation, and critical care. Massive and abrupt release of oxygen-free radicals after reperfusion triggers oxidative damage. Before critical operations or after resuscitation, it would be wise to find a suitable prophylactic treatment to avoid I/R damage. We aimed to determine whether several commonly used intravenous anesthetics protect against renal I/R injury.
Animals were randomly divided into seven groups, each consisting of six animals: sham group, control group, thiopental group, propofol group, intralipid group, etomidate group, and ketamine group. At the end of the 60-min ischemic period, 60 min reperfusion was established and the materials administered 15 min before the reperfusion. At the end of the reperfusion period, the samples of blood and tissue were reaped for biochemical and serological evaluation.
I/R procedure significantly increased malondialdehyde (MDA) levels, decreased catalase (CAT) activities, and superoxide dismutase (SOD) levels. The lowest MDA mean level was in the thiopental group and the highest MDA mean level was in control group. The lowest CAT mean level was in the intralipid group and the highest CAT mean level was in the etomidate group. The lowest SOD mean level was in the control group and the highest SOD mean level was in the propofol group.
Thiopental and propofol, especially thiopental, are more effective to protect renal I/R injury.
在包括心肌梗死、中风、主动脉手术、心肺旁路手术、器官移植、复苏和重症监护在内的许多病理情况下，都会发生缺血/再灌注（I/R）。再灌注后大量和突然释放的氧自由基引发氧化损伤。在进行关键操作之前或复苏后，明智的做法是寻找合适的预防治疗方法，以避免 I/R 损伤。我们旨在确定几种常用的静脉麻醉剂是否能预防肾 I/R 损伤。
动物随机分为七组，每组六只动物：假手术组、对照组、硫喷妥钠组、丙泊酚组、脂肪乳剂组、依托咪酯组和氯胺酮组。在缺血 60 分钟结束时，建立 60 分钟再灌注，并在再灌注前 15 分钟给予上述药物。再灌注期结束时，收获血液和组织样本进行生化和血清学评估。
I/R 程序显著增加了丙二醛（MDA）水平，降低了过氧化氢酶（CAT）活性和超氧化物歧化酶（SOD）水平。硫喷妥钠组的 MDA 平均水平最低，对照组的 MDA 平均水平最高。脂肪乳剂组的 CAT 平均水平最低，依托咪酯组的 CAT 平均水平最高。对照组的 SOD 平均水平最低，丙泊酚组的 SOD 平均水平最高。
硫喷妥钠和丙泊酚，特别是硫喷妥钠，对保护肾 I/R 损伤更有效。
