Geyfman Mikhail, Andersen Bogi
Departments of Medicine and Biological Chemistry, University of California-Irvine, Irvine CA 92697, USA.
Aging (Albany NY). 2010 Mar 31;2(3):122-8. doi: 10.18632/aging.100130.
Hair follicles undergo continuous cycles of growth, involution and rest. This process, referred to as the hair growth cycle, has a periodicity of weeks to months. At the same time, skin and hair follicles harbor a functional circadian clock that regulates gene expression with a periodicity of approximately twenty four hours. In our recent study we found that circadian clock genes play a role in regulation of the hair growth cycle during synchronized hair follicle cycling, uncovering an unexpected connection between these two timing systems within skin. This work, therefore, indicates a role for circadian clock genes in a cyclical process of much longer periodicity than twenty four hours.
毛囊经历持续的生长、退化和休止周期。这个过程，即毛发生长周期，周期为数周数月。同时，皮肤和毛囊拥有一个功能性昼夜节律时钟，以大约二十四小时的周期调节基因表达。在我们最近的研究中，我们发现昼夜节律时钟基因在同步毛囊周期期间对毛发生长周期的调节中发挥作用，揭示了皮肤内这两个计时系统之间意想不到的联系。因此，这项工作表明昼夜节律时钟基因在一个周期比二十四小时长得多的周期性过程中发挥作用。
