Amor Souheila, Châlons Pauline, Aires Virginie, Delmas Dominique
Université de Bourgogne-Franche Comté, Dijon F-21000, France.
Centre de Recherche INSERM U1231-Cancer and Adaptative Immune Response Team⁻Bioactive Molecules and Health research group, Dijon F-21000, France.
Diseases. 2018 Nov 18;6(4):106. doi: 10.3390/diseases6040106.
Wine has been popular worldwide for many centuries and currently remains an important component of our diet. Scientific interest in wine and its health effects has grown considerably since the 1990s with the emergence of the "French Paradox" concept, correlating moderate wine consumption, a characteristic of the Mediterranean diet, and low incidence of coronary heart diseases. Since then, the positive effects on health, health promotion, disease prevention, and disease prognosis of moderate wine consumption, in particular red wine, have been attributed to its polyphenolic compounds such as resveratrol, quercetin, and other flavonoids acting as antioxidants. Several epidemiological, in vivo and in vitro, studies have reported that moderate red wine or red wine polyphenolic extract consumption may be active in the prevention and treatment of chronic diseases such as cardiovascular disease, metabolic syndrome, degenerative pathologies, and cancer. The aim of this review is to summarize the current findings about the effects of red wine polyphenols on cancer and to discuss how the polyphenolic composition of red wine may influence its chemopreventive properties.
几个世纪以来，葡萄酒在全球都很受欢迎，目前仍然是我们饮食中的一个重要组成部分。自20世纪90年代“法国悖论”概念出现以来，科学界对葡萄酒及其健康影响的兴趣大幅增长，该概念将适度饮用葡萄酒（地中海饮食的一个特点）与冠心病的低发病率联系起来。从那时起，适度饮用葡萄酒，特别是红酒，对健康、健康促进、疾病预防和疾病预后的积极影响，就归因于其多酚类化合物，如白藜芦醇、槲皮素和其他作为抗氧化剂的黄酮类化合物。一些流行病学、体内和体外研究报告称，适度饮用红酒或食用红酒多酚提取物可能对预防和治疗慢性疾病，如心血管疾病、代谢综合征、退行性病变和癌症有积极作用。这篇综述的目的是总结目前关于红酒多酚对癌症影响的研究结果，并讨论红酒的多酚成分如何影响其化学预防特性。
