不同的方法适用于不同的情况：局灶性脑缺血动物模型的丰富多样性。
Different strokes for different folks: the rich diversity of animal models of focal cerebral ischemia.
机构信息
National Stroke Research Institute and University of Melbourne Department of Medicine, Austin Health, Melbourne, Victoria, Australia.
出版信息
J Cereb Blood Flow Metab. 2010 Aug;30(8):1412-31. doi: 10.1038/jcbfm.2010.66. Epub 2010 May 19.
Abstract
No single animal model is able to encompass all of the variables known to affect human ischemic stroke. This review highlights the major strengths and weaknesses of the most commonly used animal models of acute ischemic stroke in the context of matching model and experimental aim. Particular emphasis is placed on the relationships between outcome and underlying vascular variability, physiologic control, and use of models of comorbidity. The aim is to provide, for novice and expert alike, an overview of the key controllable determinants of experimental stroke outcome to help ensure the most effective application of animal models to translational research.
摘要
没有任何单一的动物模型能够涵盖所有已知会影响人类缺血性中风的变数。本综述主要针对模型和实验目的相匹配的情况下，突显最常被使用的急性缺血性中风动物模型的主要优缺点。特别强调的是，结果与潜在血管变异性、生理控制以及合并症模型使用之间的关系。其目的是为初学者和专家提供实验性中风结果的关键可控决定因素概述，以帮助确保动物模型在转化研究中的最有效应用。
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