Duffield Todd F, Heinrich Anneliese, Millman Suzanne T, DeHaan Andrew, James Shelley, Lissemore Kerry
Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1.
Can Vet J. 2010 Mar;51(3):283-8.
This study assessed the efficacy of ketoprofen for mitigating pain following dehorning with an electric cautery iron. Forty Holstein heifer calves, 4 to 8 wk of age, were randomized to receive a lidocaine cornual nerve block and either an injection of ketoprofen (3 mg/kg IM) or physiological saline, 10 min prior to dehorning. Cortisol was measured from serum obtained 10 min prior to dehorning and at 3 and 6 h post-dehorning. Calf behavior was video-recorded between 0 to 2, 3 to 5, and 6 to 8 h post-dehorning, and frequency of ear flicks, head shakes, head rubs, lying, standing, feeding, and grooming were recorded. Finally, 24-h intake of calf starter was recorded. There was no effect of treatment on cortisol (P > 0.1); however, ketoprofen-treated calves displayed less ear-flicks and total head behavior (P < 0.05), and tended to consume more starter (P = 0.09) than control calves. Ketoprofen is effective for mitigating behavioral effects of postsurgical pain following dehorning in 4- to 8-week-old calves.
本研究评估了酮洛芬对减轻电烙去角术后疼痛的疗效。40头4至8周龄的荷斯坦小母牛犊被随机分组,在去角前10分钟接受利多卡因角神经阻滞,并注射酮洛芬(3毫克/千克,肌肉注射)或生理盐水。在去角前10分钟以及去角后3小时和6小时采集血清,测定皮质醇水平。在去角后0至2小时、3至5小时和6至8小时对犊牛行为进行视频记录,并记录甩耳、摇头、蹭头、躺卧、站立、进食和梳理毛发的频率。最后,记录犊牛开食料24小时摄入量。治疗对皮质醇水平无影响(P>0.1);然而,与对照组犊牛相比,酮洛芬治疗组犊牛的甩耳次数和头部整体行为较少(P<0.05),且开食料摄入量有增加趋势(P=0.09)。酮洛芬可有效减轻4至8周龄犊牛去角术后疼痛的行为影响。