Gerardi Maryrose, Rothbaum Barbara O, Astin Millie C, Kelley Mary
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine.
J Aggress Maltreat Trauma. 2010 Jun 1;19(4):349-356. doi: 10.1080/10926771003781297.
This study examined changes in salivary cortisol levels pre-to-post-treatment in adult female rape victims diagnosed with post traumatic stress disorder (PTSD) randomly assigned to be treated with either Prolonged Exposure Therapy or Eye Movement Desensitization and Reprocessing. Salivary cortisol was collected at baseline, session 3, and session 9. A significant decrease in salivary cortisol levels was observed in individuals classified as treatment responders in both treatment conditions. Findings suggest that successful exposure-based treatments for PTSD which result in trauma-related and depressive symptom reduction may impact the action of the hypothalamic-pituitary-adrenal axis as measured by changes in level of salivary cortisol from pre-to-post-treatment.
本研究调查了被诊断患有创伤后应激障碍（PTSD）的成年女性强奸受害者在治疗前后唾液皮质醇水平的变化。这些受害者被随机分配接受延长暴露疗法或眼动脱敏再处理疗法。在基线、第3次治疗和第9次治疗时收集唾液皮质醇。在两种治疗条件下被归类为治疗有反应者的个体中，观察到唾液皮质醇水平显著下降。研究结果表明，成功的基于暴露的PTSD治疗可减轻与创伤相关的症状和抑郁症状，这可能会影响下丘脑-垂体-肾上腺轴的活动，这可通过治疗前后唾液皮质醇水平的变化来衡量。
