Cell Biology Program, Research Institute, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON M5G 1X8, Canada.
Nat Rev Gastroenterol Hepatol. 2010 Sep;7(9):503-14. doi: 10.1038/nrgastro.2010.117. Epub 2010 Jul 27.
The use of probiotics is increasing in popularity for both the prevention and treatment of a variety of diseases. While a growing number of well-conducted, prospective, randomized, controlled, clinical trials are emerging and investigations of underlying mechanisms of action are being undertaken, questions remain with respect to the specific immune and physiological effects of probiotics in health and disease. This Review considers recent advances in clinical trials of probiotics for intestinal disorders in both adult and pediatric populations. An overview of recent in vitro and in vivo research related to potential mechanisms of action of various probiotic formulations is also considered.
益生菌的使用越来越普及,可用于预防和治疗各种疾病。虽然越来越多设计良好、前瞻性、随机、对照、临床试验正在涌现,对潜在作用机制的研究也在进行,但益生菌在健康和疾病中的具体免疫和生理作用仍存在疑问。本综述考虑了益生菌在成人和儿科肠道疾病中的临床试验的最新进展。还概述了与各种益生菌配方的潜在作用机制相关的最近的体外和体内研究。