Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Department of Clinical Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Molecules. 2018 Feb 12;23(2):394. doi: 10.3390/molecules23020394.
The organic extract of liquid cultures of the marine-derived sp. was investigated. Fractionation of the extracts of the fungus led to the purification and identification of two new compounds, penicillatides A () and B (), together with the previously reported cyclo(-Pro-Phe) () and cyclo(-Pro-Phe) (). The structures of compounds - were assigned by extensive interpretation of their NMR and high-resolution mass spectrometry (HRMS). The antiproliferative and cytotoxic activities of the compounds against three human cancer cell lines as well as their antimicrobial activity against several pathogens were evaluated. Compounds - displayed variable cytotoxic and antimicrobial activities.
对海洋来源的 sp. 的液体培养物的有机提取物进行了研究。真菌提取物的分级分离导致了两种新化合物的纯化和鉴定，分别为 penicillatides A () 和 B ()，以及之前报道的 cyclo(-Pro-Phe) () 和 cyclo(-Pro-Phe) ()。化合物 - 的结构通过对其 NMR 和高分辨率质谱 (HRMS) 的广泛解释来确定。评估了这些化合物对三种人类癌细胞系的抗增殖和细胞毒性活性以及对几种病原体的抗菌活性。化合物 - 表现出不同的细胞毒性和抗菌活性。
