Garcia Ricardo V, Gabrielli Marisa A Cabrini, Hochuli-Vieira Eduardo, Spolidorio Luis C, Filho Joao G Padilha, Neto Francisco A Doria, de Cardoso Luciana A Gouveia, Shibli Jamil A
Division of Periodontology, Dental School at Araraquara, São Paulo State University, São Paulo, Brazil.
J Oral Implantol. 2010;36(4):281-90. doi: 10.1563/AAID-JOI-D-09-00056.
The present study evaluated the effect of platelet-rich plasma (PRP) on peri-implant bone healing. A total of 9 mongrel dogs received 36 dental implants with sandblasted acid-etched surface in lower jaws in a split-mouth design: in the PRP group (n=18 implants) the implants were placed in association with PRP, and in the control group (n=18 implants) the implants were placed without PRP. Biopsies were obtained and prepared for histologic and histometric analysis after 15, 30, and 55 days of healing. The biopsies retrieved at 15 days showed delicate bone trabeculae formed by immature bone with presence of numerous osteoblasts for both groups. At 30 days the trabeculae presented reversal lines and evident lamellar disposition, where some thread spaces were filled by bone and dense connective tissue. At 55 days, bone healing was not altered in the control group, and histologic aspects were variable for the group treated with PRP. There was no significant difference between the groups for bone-to-implant contact (P>.05). PRP did not enhance bone formation around sandblasted acid-etched implants.
本研究评估了富血小板血浆（PRP）对种植体周围骨愈合的影响。采用分口设计，将9只杂种犬下颌植入36颗具有喷砂酸蚀表面的牙种植体：在PRP组（n = 18颗种植体）中，种植体与PRP联合植入；在对照组（n = 18颗种植体）中，种植体在无PRP的情况下植入。愈合15、30和55天后获取活检样本并进行组织学和组织计量学分析。15天时获取的活检样本显示，两组均有由未成熟骨形成的纤细骨小梁，并有大量成骨细胞。30天时，骨小梁出现反转线和明显的板层排列，一些螺纹间隙被骨和致密结缔组织填充。55天时，对照组的骨愈合未改变，而PRP治疗组的组织学表现各异。两组之间的骨-种植体接触无显著差异（P>0.05）。PRP并未增强喷砂酸蚀种植体周围的骨形成。
