HIV-1 感染者中的甲型 H1N1 流感大流行。

Pandemic influenza A (H1N1) in HIV-1-infected patients.

机构信息

Department of Medicine, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.

出版信息

AIDS. 2010 Nov 27;24(18):2867-9. doi: 10.1097/QAD.0b013e32833e92d5.

DOI:10.1097/QAD.0b013e32833e92d5

PMID:20802295

Abstract

OBJECTIVE

To characterize the clinical presentation, course and mortality of pandemic influenza in HIV-1-infected patients in Santiago, Chile.

METHODS

Prospective observational study.

RESULTS

Thirty patients were included (three hospitalized), 93% were on HAART, mean CD4(+) cell count was 423 cells/μl and viral load was undetectable in 77% of patients. All patients had fever, 90% had cough, 80% had myalgias, 70% had pharyngeal congestion, 47% had coryza, 47% had odynophagia, 37% had headache and 23% had vomiting. Four patients developed pneumonia. All patients received antiviral therapy and no patient died.

CONCLUSIONS

HIV patients infected by the new influenza A pandemic (H1N1) virus behave similarly to the general population.

摘要

目的

描述智利圣地亚哥 HIV-1 感染者中流行流感的临床特征、病程和死亡率。

方法

前瞻性观察性研究。

结果

共纳入 30 例患者（3 例住院），93%的患者正在接受高效抗逆转录病毒治疗，平均 CD4(+)细胞计数为 423 个/μl，77%的患者病毒载量不可检测。所有患者均有发热，90%有咳嗽，80%有肌痛，70%有咽部充血，47%有鼻塞，47%有咽痛，47%有头痛，23%有呕吐。4 例患者发生肺炎。所有患者均接受了抗病毒治疗，无患者死亡。