Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Br J Cancer. 2010 Oct 12;103(8):1144-8. doi: 10.1038/sj.bjc.6605901. Epub 2010 Sep 21.
MicroRNAs (miRNAs) are small non-protein-coding RNAs that function as endogenous negative gene regulators. Dysfunctions of miRNAs are frequently found in malignancies, including lung cancer. In this review, we summarise the current understanding of miRNAs in lung cancer tumourigenesis, and highlight their potential in overcoming drug resistance, abetting histological sub-classification techniques, and serving as biomarkers for lung cancer risk stratification and outcome prediction.
微小 RNA(miRNAs)是一种小的非蛋白编码 RNA,作为内源性负基因调节剂发挥作用。miRNAs 的功能障碍在包括肺癌在内的恶性肿瘤中经常被发现。在这篇综述中,我们总结了 miRNAs 在肺癌肿瘤发生中的最新认识,并强调了它们在克服耐药性、辅助组织学亚分类技术、作为肺癌风险分层和预后预测的生物标志物方面的潜在应用。