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器官移植后中心效能的测量和比较方法综述。

Review of methods for measuring and comparing center performance after organ transplantation.

机构信息

Directorate for Organ Donation and Transplantation, National Health Service Blood and Transplant, Bristol, United Kingdom.

出版信息

Liver Transpl. 2010 Oct;16(10):1119-28. doi: 10.1002/lt.22131.

Abstract

The assessment of outcomes after transplantation is important for several reasons: it provides patients with data so that they can make informed decisions about the benefits of transplantation and the success of the transplant unit; it informs commissioners that resources are allocated properly; and it provides clinicians reassurance that results are acceptable or, if they are not, provides early warning so that problems can be identified, corrections can be instituted early, and all interested parties can be reassured that scarce resources are used fairly. The need for greater transparency in reporting outcomes after liver transplantation and for comparisons both between and within centers has led to a number of approaches being adopted for monitoring center performance. We review some of the commonly used methods, highlight their strengths and weaknesses, and concentrate on methods that incorporate risk adjustment. Measuring and comparing outcomes after transplantation is complex, and there is no single approach that gives a complete picture. All those using analyses of outcomes must understand the merits and limitations of individual methods. When used properly, such methods are invaluable in ensuring that a scarce resource is used effectively, any adverse trend in outcomes is identified promptly and remedied, and best performers are identified; they thus allow the sharing of best practices. However, when they are used inappropriately, such measurements may lead to inappropriate conclusions, encourage risk-averse behavior, and discourage innovation.

摘要

移植后结果的评估很重要,原因有几个:它为患者提供数据,以便他们可以就移植的益处和移植单位的成功做出明智的决策;它告知决策者资源分配是否得当;它还让临床医生放心,结果是可以接受的,或者如果不可接受,则提供早期警告,以便可以发现问题,尽早进行纠正,并且所有相关方都可以放心,稀缺资源得到公平使用。由于需要提高肝移植后结果报告的透明度,并在中心之间以及中心内部进行比较,因此采用了许多方法来监测中心的表现。我们回顾了一些常用的方法,强调了它们的优缺点,并集中讨论了纳入风险调整的方法。测量和比较移植后的结果很复杂,没有一种方法可以提供完整的情况。所有使用结果分析的人都必须了解个别方法的优点和局限性。如果使用得当,这些方法对于确保有效利用稀缺资源、及时发现和纠正任何不良趋势以及识别最佳表现者非常有价值;它们还允许分享最佳实践。但是,如果使用不当,这些测量可能会导致不当的结论,鼓励规避风险的行为,并阻碍创新。

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