Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine, Kenya Medical Research Institute/University of Oxford-Wellcome Trust Research Programme, Kenyatta National Hospital Grounds, Nairobi, Kenya.
Am J Trop Med Hyg. 2010 Oct;83(4):854-60. doi: 10.4269/ajtmh.2010.10-0331.
In some countries the biological targeting of universal malaria prevention may offer optimal impact on disease and significant cost-savings compared with approaches that presume universal risk. Spatially defined data on coverage of treated nets from recent national household surveys in Kenya were used within a Bayesian geostatistical framework to predict treated net coverage nationally. When combined with the distributions of malaria risk and population an estimated 8.1 million people were not protected with treated nets in 2010 in biologically defined priority areas. After adjusting for the proportion of nets in use that were not long lasting, an estimated 5.5 to 6.3 million long-lasting treated nets would be required to achieve universal coverage in 2010 in Kenya in at-risk areas compared with 16.4 to 18.1 million nets if not restricted to areas of greatest malaria risk. In Kenya, this evidence-based approach could save the national program at least 55 million US dollars.
在一些国家,与假定普遍存在风险的方法相比,针对普遍存在的疟疾进行生物靶向预防可能会对疾病产生最佳影响,并显著节省成本。利用肯尼亚最近的全国家庭调查中关于处理过的蚊帐覆盖范围的空间定义数据,在贝叶斯地统计学框架内对全国范围内的处理过的蚊帐覆盖范围进行了预测。将疟疾风险和人口的分布情况结合起来,可以估计在 2010 年,在生物定义的重点地区,有 810 万人没有得到处理过的蚊帐的保护。在对未使用的、不持久的蚊帐比例进行调整后,估计在 2010 年,肯尼亚的高风险地区需要 550 万至 630 万顶长效处理过的蚊帐才能实现普及,而如果不局限于疟疾风险最大的地区,则需要 1640 万至 1810 万顶。在肯尼亚,这种基于证据的方法至少可以为国家项目节省 5500 万美元。