Centre for Pathophysiology, Infectiology and Immunology, Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria.
Wien Klin Wochenschr. 2010 Oct;122 Suppl 3:52-6. doi: 10.1007/s00508-010-1438-6.
The increasing drug resistance of Plasmodium falciparum is a worldwide problem. The objective of the study was the assessment of the in vitro activity of artemisinin, mefloquine and quinine, in an area where P. falciparum is multi-drug resistant. The sensitivity tests were based on measuring the drug-dependent inhibition of schizont maturation. For the 43 successfully tested isolates the mean effective concentrations (IC(50) and IC(90)) for artemisinin were 0.0081 and 0.1372 μM, respectively. For mefloquine the IC(50) was 0.1260 μM and the IC(90) was 3.7345 μM. Quinine showed an IC(50) of 0.2155 μM and an IC(90) of 2.5040 μM. All tested drugs showed a significant reduction in the effectiveness, compared with the results of former years. This suggests a further rise of resistance of local P. falciparum, which is alarming especially for artemisinin and quinine.
疟原虫对青蒿素类药物的抗药性日益增强，是一个全球性问题。本研究的目的是评估青蒿素、甲氟喹和奎宁在一个疟原虫多药耐药地区的体外活性。敏感性试验基于测量裂殖体成熟的药物依赖性抑制作用。对 43 株成功检测的分离株，青蒿素的平均有效浓度（IC50 和 IC90）分别为 0.0081 和 0.1372 μM。甲氟喹的 IC50 为 0.1260 μM，IC90 为 3.7345 μM。奎宁的 IC50 为 0.2155 μM，IC90 为 2.5040 μM。与前几年的结果相比，所有测试药物的有效性都显著降低。这表明当地疟原虫的抗药性进一步上升，这尤其令人担忧的是青蒿素和奎宁。
