La Vecchia C, Bidoli E, Barra S, D'Avanzo B, Negri E, Talamini R, Franceschi S
Istituto di Richerche Farmacologiche Mario Negri, Milano, Italy.
Cancer Causes Control. 1990 Jul;1(1):69-74. doi: 10.1007/BF00053185.
The relationship between type of cigarettes smoked and the risk of cancer of upper digestive and respiratory sites was investigated in a case-control study conducted in Northern Italy on 291 males with cancer of the oral cavity or pharynx, 288 with cancer of the esophagus, 162 with cancer of the larynx, and 1,272 control subjects in hospital for acute conditions unrelated to tobacco or alcohol consumption. Using a distinction based on tar-yield or the brand smoked for the longest time (less than 22 mg, low to medium tar; greater than or equal to 22 mg, high tar), the multivariate relative risks among ever-smokers were 8.5 for low/medium and 16.4 for high tar cigarettes for oral and pharyngeal neoplasms, 3.3 and 7.8 for esophageal, and 4.8 and 7.1 for laryngeal cancers. The differences according to type of cigarettes were similar in proportional terms, and hence larger in absolute terms, when analysis was restricted to current smokers only. Thus, these data provide further quantitative evidence on the importance of type of cigarette smoked on the risk of upper-digestive and respiratory tract cancers and have important public health implications.
在意大利北部开展的一项病例对照研究中，调查了所吸香烟类型与上消化道和呼吸道癌症风险之间的关系。该研究选取了291名患有口腔癌或咽癌的男性、288名患有食管癌的男性、162名患有喉癌的男性，以及1272名因与烟草或酒精消费无关的急性病住院的对照对象。根据焦油含量或吸食时间最长的香烟品牌（低于22毫克，低至中焦油；大于或等于22毫克，高焦油）进行区分，在曾经吸烟者中，对于口腔和咽肿瘤，低/中焦油香烟的多变量相对风险为8.5，高焦油香烟为16.4；对于食管癌，分别为3.3和7.8；对于喉癌，分别为4.8和7.1。仅对当前吸烟者进行分析时，根据香烟类型的差异在比例上相似，因此绝对差异更大。因此，这些数据为所吸香烟类型对上消化道和呼吸道癌症风险的重要性提供了进一步的定量证据，并具有重要的公共卫生意义。
