von Bonsdorff C H, Hovi T, Mäkelä P, Mörttinen A
J Med Virol. 1978;2(1):21-8. doi: 10.1002/jmv.1890020105.
During an epidemic of acute gastroenteritis in Helsinki, in March--May 1976, 18 out of 40 adult patients showed electron microscopic and/or serologic evidence for rotavirus infection. Rotavirus was most frequently seen in the fecal suspensions from 2 to 6 days after the onset of the symptoms but persisted in one patient for as long as 10 days. An increase in the complement-fixing (CF) serum antibody titers against the related Nebraska calf diarrhea virus (NCDV), or an initially high titer and subsequent significant decrease, was seen in all but one patient with rotavirus-positive feces, and in 6 additional patients. This suggests that using electron microscopy as the only diagnostic procedure a considerable number of rotavirus infections in adults remain undetected. Immune response against autologous or homologous rotavirus was also documented by immunoelectron microscopy. Complement-fixing antibody titers against NCDV decreased significantly from the convalescence values over a half-year observation period, but still remained clearly above the titers of a gastroenteritis-negative control population.
1976年3月至5月赫尔辛基发生急性胃肠炎疫情期间，40名成年患者中有18人呈现出轮状病毒感染的电子显微镜和/或血清学证据。轮状病毒最常见于症状出现后2至6天的粪便悬液中，但在一名患者中持续长达10天。除一名粪便轮状病毒呈阳性的患者外，所有患者以及另外6名患者均出现针对相关内布拉斯加小牛腹泻病毒（NCDV）的补体结合（CF）血清抗体滴度升高，或起初滴度较高随后显著下降的情况。这表明仅将电子显微镜作为诊断方法时，大量成人轮状病毒感染仍未被发现。免疫电子显微镜也记录了针对自体或同源轮状病毒的免疫反应。在半年的观察期内，针对NCDV的补体结合抗体滴度从恢复期的值显著下降，但仍明显高于胃肠炎阴性对照人群的滴度。
