Rao Vasudev Anand, Pandian Datta Gulnar, Kasturi Nirupama, Muthukrishanan V, Thappa D M
Department of Ophthalmology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry - 605 006, India.
Indian J Dermatol. 2010 Jul-Sep;55(3):268-70. doi: 10.4103/0019-5154.70686.
Systemic lupus erythematosus (SLE) affects the eye as part of the disease or due to the drugs used in therapy. Ocular involvement is seen in one third of the patients with SLE. SLE is rare in India and found less frequently in males and children. SLE retinopathy is usually bilateral. We report an unusual case of unilateral macular infarction in a boy caused by systemic lupus erythematosus. A fourteen year old boy was presented with skin rashes and loss of vision in left eye. Posterior segment examination showed hyperemic edematous disc, arteriolar attenuation, venous dilatation, multiple cotton wool spots around the disc and macula in the left eye. There was no improvement in vision with pulse steroids and cyclophosphamide. The clinical implication of SLE retinopathy is that the disease is severe and warrants systemic immunosuppressive therapy. SLE-induced macular infarction is rare and has poor visual prognosis. As serious ocular complications of SLE can be silent, routine ophthalmological evaluation is warranted in all patients.
系统性红斑狼疮(SLE)可作为疾病的一部分累及眼部,或因治疗所用药物而累及眼部。三分之一的SLE患者会出现眼部受累情况。SLE在印度较为罕见,在男性和儿童中更为少见。SLE视网膜病变通常为双侧性。我们报告一例由系统性红斑狼疮引起的男孩单侧黄斑梗死的罕见病例。一名14岁男孩出现皮疹及左眼视力丧失。眼部后段检查显示左眼视盘充血水肿、小动脉变细、静脉扩张、视盘及黄斑周围有多个棉絮斑。使用脉冲类固醇和环磷酰胺治疗后视力无改善。SLE视网膜病变的临床意义在于该疾病较为严重,需要进行全身免疫抑制治疗。SLE引起的黄斑梗死罕见,视力预后较差。由于SLE的严重眼部并发症可能没有症状,因此所有患者都应进行常规眼科评估。