Institute of Microbiology, Academy of Sciences of the Czech Republic, Vídeňská 1083, 14220 Prague 4, Czech Republic.
J Ind Microbiol Biotechnol. 2010 Dec;37(12):1241-8. doi: 10.1007/s10295-010-0849-8. Epub 2010 Nov 18.
Resistance to antibiotics and other antimicrobial compounds continues to increase. There are several possibilities for protection against pathogenic microorganisms, for instance, preparation of new vaccines against resistant bacterial strains, use of specific bacteriophages, and searching for new antibiotics. The antibiotic search includes: (1) looking for new antibiotics from nontraditional or less traditional sources, (2) sequencing microbial genomes with the aim of finding genes specifying biosynthesis of antibiotics, (3) analyzing DNA from the environment (metagenomics), (4) re-examining forgotten natural compounds and products of their transformations, and (5) investigating new antibiotic targets in pathogenic bacteria.
抗生素和其他抗菌化合物的耐药性持续增加。有几种保护措施可以对抗致病微生物，例如，制备针对耐药菌的新疫苗，使用特定噬菌体，以及寻找新的抗生素。抗生素的寻找包括：（1）从非传统或较少传统的来源寻找新的抗生素，（2）对微生物基因组进行测序，以寻找指定抗生素生物合成的基因，（3）分析环境中的 DNA（宏基因组学），（4）重新检查被遗忘的天然化合物及其转化产物，以及（5）研究致病菌中新的抗生素靶标。
