School of Human Movement Studies, Charles Sturt University, Panorama Avenue, Bathurst, NSW 2795, Australia.
Eur J Appl Physiol. 2011 Jun;111(6):1035-45. doi: 10.1007/s00421-010-1724-z. Epub 2010 Nov 19.
This study sought to compare the respective effects of resistance or aerobic exercise of higher or lower intensities on the acute plasma interleukin-6 (IL-6) and C-reactive protein (CRP) response in a sedentary, middle-aged, disease-free cohort. Following baseline testing, and in a randomized cross-over design, 12 sedentary males completed four exercise protocols, including 40 min of moderate-vigorous (M-VA) or low-intensity (LA) aerobic exercise on a cycle ergometer; and a moderate-vigorous (M-VR) or low-intensity (LR) full-body resistance session matched for protocol duration. Venous blood was obtained pre-, post-, 3 h post and 24 h post-exercise and analysed for IL-6, CRP, leukocyte count, myoglobin, creatine kinase (CK), and cortisol. Diet and physical activity were standardized 24 h before and after exercise. Results indicated an elevated CRP response in the M-VR protocol in comparison to the low-intensity protocols (P < 0.05); however, no changes were evident between the moderate-vigorous intensity protocols. The moderate-vigorous intensity protocols induced significant increases of IL-6, cortisol, and leukocytes in comparison to the low-intensity protocols (P < 0.05). However, the IL-6 response showed no significant differences between the moderate-vigorous intensity protocols, despite the M-VR protocol inducing the largest response of markers indicative of muscle damage (CK, myoglobin, and neutrophil count) (P < 0.05). Hence, indicating a disassociation between the IL-6 response and markers of muscle damage within the respective exercise bouts. The highest IL-6 response was evident in the moderate-vigorous intensity protocols immediately post-exercise. Moreover, the exercise modality did not seem to influence the acute IL-6 and CRP response, with the main determinant of the IL-6 response being exercise intensity.
本研究旨在比较不同强度的抗阻或有氧训练对静息、中年、无疾病人群的急性血浆白细胞介素-6（IL-6）和 C 反应蛋白（CRP）反应的影响。在基线测试后，采用随机交叉设计，12 名静息男性完成了四项运动方案，包括在自行车功量计上进行 40 分钟的中高强度（M-VA）或低强度（LA）有氧运动；以及中高强度（M-VR）或低强度（LR）全身抗阻运动，持续时间相同。在运动前、运动后、运动后 3 小时和 24 小时采集静脉血，分析 IL-6、CRP、白细胞计数、肌红蛋白、肌酸激酶（CK）和皮质醇。在运动前后 24 小时内饮食和体力活动标准化。结果表明，与低强度方案相比，M-VR 方案中 CRP 反应升高（P<0.05）；然而，中高强度方案之间没有明显变化。与低强度方案相比，中高强度方案显著增加了 IL-6、皮质醇和白细胞（P<0.05）。然而，中高强度方案之间的 IL-6 反应没有显著差异，尽管 M-VR 方案诱导了最大的肌损伤标志物（CK、肌红蛋白和中性粒细胞计数）的反应（P<0.05）。因此，表明在各自的运动过程中，IL-6 反应与肌肉损伤标志物之间存在脱偶联。在运动后即刻，中高强度方案中 IL-6 反应最高。此外，运动方式似乎不会影响急性 IL-6 和 CRP 反应，IL-6 反应的主要决定因素是运动强度。
