Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, 20 Renmingnan Road, Chengdu, China.
Int J Gynaecol Obstet. 2011 Feb;112(2):131-4. doi: 10.1016/j.ijgo.2010.08.010. Epub 2010 Nov 19.
To study the prevalence and genotype distribution of human papillomavirus (HPV) among women with cervical cancer or high-grade squamous intraepithelial lesions (HSIL) in western China.
Cervical cast-off cells from 144 women with cervical cancer and 63 women with HSIL were tested for HPV genotypes using an oligonucleotide microarray.
The overall HPV prevalence was 80.6% in cases of carcinoma and 61.9% in cases of HSIL. The most common genotypes were HPV-16 (carcinoma, 68.1%; HSIL, 34.9%) and HPV-58 (carcinoma, 8.3%; HSIL, 17.5%). Other high-risk types included HPV-18, -31, -33, -35, -45, and -52, with HPV-18 more common in adenocarcinomas than in squamous cell carcinomas (21.4% vs 3.1%; P<0.02). The HPV prevalence was lower among patients older than 49 years (P<0.02).
The prevalence of HPV-16 and HPV-58 was high. This finding may help to improve HPV vaccination and cervical cancer prevention programs in western China.
研究中国西部地区宫颈癌或高级别鳞状上皮内病变（HSIL）妇女中人类乳头瘤病毒（HPV）的流行率和基因型分布。
采用寡核苷酸微阵列法检测 144 例宫颈癌和 63 例 HSIL 妇女的宫颈脱落细胞 HPV 基因型。
宫颈癌病例 HPV 总流行率为 80.6%，HSIL 病例为 61.9%。最常见的基因型是 HPV-16（宫颈癌，68.1%；HSIL，34.9%）和 HPV-58（宫颈癌，8.3%；HSIL，17.5%）。其他高危型包括 HPV-18、-31、-33、-35、-45 和 -52，HPV-18 在腺癌中比在鳞癌中更为常见（21.4%比 3.1%；P<0.02）。49 岁以上患者的 HPV 流行率较低（P<0.02）。
HPV-16 和 HPV-58 的流行率较高。这一发现可能有助于改善中国西部地区的 HPV 疫苗接种和宫颈癌预防计划。
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