Farshid Amir Abbas, Tamaddonfard Esmaeal, Yahyaee Fatere
Division of Pathology, Department of Pathobiology, Faculty of Veterinary Medicine, P.O. Box 1177, Urmia University, Urmia 57153, Iran.
Indian J Exp Biol. 2010 Nov;48(11):1136-42.
The intra-plantar injection of carrageenan elicited an inflammatory response characterized by increase of the paw thickness and infiltration of neutrophils in paw tissues. Histidine, n-acetylcysteine and diclofenac decreased paw thickness, and neutrophil infiltration in the paw tissues. The anti-inflammatory effect induced by co-administration of histidine and n-acetylcysteine with diclofenac, was more than that obtained from histidine and n-acetylcysteine administered alone. The results suggested that histidine, n-acetylcysteine and diclofenac produced anti-inflammatory activities by reducing paw edema and neutrophil infiltrationin induced by carrageenan. Inhibition of cyclooxygenase products such as prostaglandins may be involved in the anti-inflammatory effects induced by histidine and n-acetylcysteine.
将角叉菜胶注射到足底会引发炎症反应，其特征为爪部厚度增加以及爪部组织中嗜中性粒细胞浸润。组氨酸、N-乙酰半胱氨酸和双氯芬酸可降低爪部厚度以及爪部组织中的嗜中性粒细胞浸润。组氨酸和N-乙酰半胱氨酸与双氯芬酸联合给药所诱导的抗炎作用，比单独给予组氨酸和N-乙酰半胱氨酸所获得的抗炎作用更强。结果表明，组氨酸、N-乙酰半胱氨酸和双氯芬酸通过减轻角叉菜胶诱导的爪部水肿和嗜中性粒细胞浸润而产生抗炎活性。组氨酸和N-乙酰半胱氨酸所诱导的抗炎作用可能涉及对环氧合酶产物（如前列腺素）的抑制。
