Oguchi H, Terashima M, Tokunaga S, Kiyosawa K, Tanaka E, Furuta S, Kanno Y, Aizawa T, Nishioka K
Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Nihon Jinzo Gakkai Shi. 1990 Mar;32(3):313-7.
The prevalence of hepatitis C virus (HCV) infection in patients with long-term hemodialysis (HD) in Japan was assessed using an Ortho HCV Antibody ELISA TEST system. Out of 51 patients, 48 of whom had a history of blood transfusions, 15 (29%) were positive for anti-HCV. This figure is much higher than that in other countries (1-20%), and the difference may reflect a select population. Six (33%) of 18 HD patients with chronic hepatic disease were anti-HCV positive. On the other hand, the prevalence of hepatitis B virus (HBV) markers was 39% (20/51), and 7 (35%) of these 20 with HBV markers were also positive for HCV. The prevalence of anti-HCV showed no relation to the duration of HD treatment. Although a correlation between the prevalence and the blood units transfused was not demonstrated, anti-HCV positive patients had received blood transfusions amounting to significantly more units than those given to negative patients. Anti-HCV was detected in approximately one-third of patients with long-term HD, indicating a lower prevalence of HCV infection as compared to that of HBV infection, and patients with hepatitis of type C accounted for about one-third of HD patients with chronic hepatic disease.
采用奥尔特丙肝抗体酶联免疫吸附试验系统评估了日本长期血液透析（HD）患者中丙型肝炎病毒（HCV）感染的患病率。在51例患者中，其中48例有输血史，15例（29%）抗-HCV呈阳性。这一数字远高于其他国家（1%-20%），这种差异可能反映了特定人群。18例患有慢性肝病的血液透析患者中有6例（33%）抗-HCV呈阳性。另一方面，乙型肝炎病毒（HBV）标志物的患病率为39%（20/51），这20例有HBV标志物的患者中有7例（35%）HCV也呈阳性。抗-HCV的患病率与血液透析治疗时间无关。虽然未证实患病率与输血单位数之间存在相关性，但抗-HCV阳性患者接受的输血量明显多于阴性患者。在约三分之一的长期血液透析患者中检测到抗-HCV，表明HCV感染的患病率低于HBV感染，丙型肝炎患者约占患有慢性肝病的血液透析患者的三分之一。
